Systemic Immune-Inflammation Index as a Potential Biomarker for Assessing Disease Activity and Predicting Proteinuria Development in Systemic Lupus Erythematosus.

Autor:	Ergun MC; Department of Rheumatology, Numune State Hospital, Konya, TUR., Aktas E; Department of Internal Medicine, Necmettin Erbakan University, Meram Medical Faculty, Konya, TUR., Sahin AT; Department of Cardiology, Beyhekim Training and Research Hospital, Konya, TUR., İyisoy MS; Department of Medical Education, Necmettin Erbakan University, Meram Medical Faculty, Konya, TUR., Alsancak Y; Department of Cardiology, Necmettin Erbakan University, Meram Medical Faculty, Konya, TUR., Tunc R; Department of Rheumatology, Necmettin Erbakan University, Meram Medical Faculty, Konya, TUR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 28; Vol. 16 (6), pp. e63401. Date of Electronic Publication: 2024 Jun 28 (Print Publication: 2024).
DOI:	10.7759/cureus.63401
Abstrakt:	Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease with varied clinical manifestations affecting multiple organ systems. This study aimed to investigate the association between the systemic immune-inflammation index (SII) and disease activity, as well as proteinuria levels in patients with SLE. Methodology A total of 141 patients diagnosed with SLE and 99 control subjects were included in this retrospective study. SLE patients were divided into two groups based on the presence (52) or absence (89) of proteinuria. Demographic data, laboratory parameters, and disease activity scores were recorded. SII was calculated based on peripheral blood counts. Statistical analysis was performed to assess the relationship between SII levels and disease activity, as well as proteinuria. Results The statistical analysis among the three groups revealed that SII was significantly different in all three groups (p < 0.001). Moreover, within the SLE cohort, patients with proteinuria had significantly higher SII levels compared to those without proteinuria (p = 0.012). Correlation analysis revealed a positive association between SII and both proteinuria and Systemic Lupus Erythematosus Disease Activity Index 2000 (r = 0.215; p = 0.011 and r = 0.186; p = 0.028, respectively). Receiver operating characteristic analysis demonstrated that SII had potential clinical value in diagnosing SLE and predicting proteinuria development. Conclusions The findings of this study suggest that SII may serve as a useful biomarker for assessing disease activity and predicting proteinuria development in patients with SLE. Further research is warranted to validate these findings and explore the utility of SII in clinical practice for monitoring disease progression and treatment response in SLE. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Necmettin Erbakan University issued approval 2022/3970. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Ergun et al.)
Databáze:	MEDLINE
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