Heightened SAM- and HPA-axis activity during acute stress impairs decision-making: A systematic review on underlying neuropharmacological mechanisms.

Autor: van Herk L; Department of Psychiatry, University Medical Centre, Utrecht, the Netherlands.; Brain Research and Innovation Centre, Ministry of Defence, Utrecht, the Netherlands., Schilder FPM; Department of Psychiatry, University Medical Centre, Utrecht, the Netherlands.; Brain Research and Innovation Centre, Ministry of Defence, Utrecht, the Netherlands., de Weijer AD; Department of Psychiatry, University Medical Centre, Utrecht, the Netherlands.; Brain Research and Innovation Centre, Ministry of Defence, Utrecht, the Netherlands., Bruinsma B; Department of Psychiatry, University Medical Centre, Utrecht, the Netherlands.; Brain Research and Innovation Centre, Ministry of Defence, Utrecht, the Netherlands., Geuze E; Department of Psychiatry, University Medical Centre, Utrecht, the Netherlands.; Brain Research and Innovation Centre, Ministry of Defence, Utrecht, the Netherlands.
Jazyk: angličtina
Zdroj: Neurobiology of stress [Neurobiol Stress] 2024 Jul 03; Vol. 31, pp. 100659. Date of Electronic Publication: 2024 Jul 03 (Print Publication: 2024).
DOI: 10.1016/j.ynstr.2024.100659
Abstrakt: Individuals might be exposed to intense acute stress while having to make decisions with far-reaching consequences. Acute stress impairs processes required for decision-making by activating different biological stress cascades that in turn affect the brain. By knowing which stress system, brain areas, and receptors are responsible for compromised decision-making processes, we can effectively find potential pharmaceutics that can prevent the deteriorating effects of acute stress. We used a systematic review procedure and found 44 articles providing information on this topic. Decision-making processes could be subdivided into 4 domains (cognitive, motivational, affective, and predictability) and could be referenced to specific brain areas, while mostly being impaired by molecules associated with the sympathetic-adrenal-medullar and hypothalamic-pituitary-adrenal axes. Potential drugs to alleviate these effects included α 1 and β adrenoceptor antagonists, α 2 adrenoceptor agonists, and corticotropin releasing factor receptor 1/2 antagonists, while consistent stress-like effects were found with yohimbine, an α 2 adrenoceptor antagonist. We suggest possible avenues for future research.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors.)
Databáze: MEDLINE
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