Investigating the Relationship of Serum CD163, YKL40 and VILIP-1 Levels with Autism Severity and Language-cognitive Development in Preschool Children with Autism.

Autor: Demirci SC; Department of Child and Adolescent Psychiatry, Gazi University Medical Faculty, Ankara, Turkey.; Department of Child and Adolescent Psychiatry, Ardahan State Hospital, Ardahan, Turkey., Barun S; Department of Medical Pharmacology, Gazi University Medical Faculty, Ankara, Turkey., Özaslan A; Department of Child and Adolescent Psychiatry, Gazi University Medical Faculty, Ankara, Turkey.; Autism and Developmental Disorders Application and Research Center, Gazi University Ankara, Turkey., Gülbahar Ö; Department of Medical Biochemistry, Gazi University Medical Faculty, Ankara, Turkey., Bulut TSD; Department of Medical Biochemistry, Gazi University Medical Faculty, Ankara, Turkey., Çamurdan AD; Department of Child Health and Diseases, Gazi University Medical Faculty, Ankara, Turkey., İşeri E; Department of Child and Adolescent Psychiatry, Gazi University Medical Faculty, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology [Clin Psychopharmacol Neurosci] 2024 Aug 31; Vol. 22 (3), pp. 473-483. Date of Electronic Publication: 2024 Apr 24.
DOI: 10.9758/cpn.23.1149
Abstrakt: Objective: This study aimed to compare serum levels of CD163, YKL-40, and VILIP-1 between children with autism spectrum disorder (ASD) and healthy controls, while also investigating their association with the severity of ASD and language development.
Methods: The study included 40 ASD-diagnosed patients (aged 18-72 months) and 40 age-matched healthy controls. Childhood Autism Rating Scale, Preschool Language Scale-4, and Ankara Development Screening Inventory were administered to children in the ASD group. Serum CD163, YKL-40 and VILIP-1 levels were measured with an enzyme- linked immunosorbent assay kit.
Results: In the ASD group compared to the control group, serum VILIP-1 levels were significantly higher ( p = 0.046). No significant differences were observed in mean serum CD163 and YKL-40 levels between patients and controls ( p = 0.613, p = 0.769). Interestingly, a positive correlation was observed between CD163 and YKL-40 levels and ASD severity ( p < 0.001 for both). Additionally, CD163 and YKL-40 levels showed significant predictive value for ASD severity. While no significant associations were found between CD163 and YKL-40 levels and language development, a negative correlation was observed between VILIP-1 levels and language development ( p < 0.001).
Conclusion: Our findings highlight that the levels of CD163 and YKL-40 significantly predicted ASD severity, indicating a potential role of neuroinflammation in the development of ASD.
Databáze: MEDLINE
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