| Autor: |
Nakatani N; Department of Neurology, Tokyo Medical and Dental University Hospital., Ono D; Department of Neurology, Tokyo Medical and Dental University Hospital.; Department of Neuroscience, Mayo Clinic., Hirata K; Department of Neurology, Tokyo Medical and Dental University Hospital.; Department of Functional Brain Imaging, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology., Yoshioka K; Department of Neurology, Tokyo Medical and Dental University Hospital., Endo H; Department of Functional Brain Imaging, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology., Ono K; Department of Neurology, Kanazawa University., Higuchi M; Department of Functional Brain Imaging, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology., Yokota T; Department of Neurology, Tokyo Medical and Dental University Hospital. |
| Abstrakt: |
The patient was an 85-year-old man with a one-year history of difficulty reading kana. Neuropsychological evaluation revealed kana (phonogram)-selective reading impairment and kanji (ideogram)-dominant writing impairment. MRI revealed significant cerebral atrophy in the left occipital cortex, leading to the clinical diagnosis of posterior cortical atrophy (PCA). Cerebrospinal fluid amyloid β 1-42 levels were reduced, and amyloid PET showed accumulation in the posterior cingulate cortex, precuneus, and frontal lobe. In contrast, tau PET showed no accumulation in the atrophied brain areas. Episodes of REM sleep behavior disorder and decreased uptake on meta-iodobenzylguanidine (MIBG) myocardial scintigraphy suggested the involvement of Lewy body pathology. PCA with distinct laterality has been rarely reported, and this is the first case to present Kana-selective reading impairment and Kanji-dominant writing impairment with neurodegenerative background. |
