Asthma-Genomic Advances Toward Risk Prediction.

Autor:	Herrera-Luis E; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA. Electronic address: eherre11@jh.edu., Martin-Almeida M; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), Avenida Astrofísico Francisco Sánchez, s/n. Facultad de Ciencias, San Cristóbal de La Laguna, S/C de Tenerife La Laguna 38200, Tenerife, Spain., Pino-Yanes M; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), Avenida Astrofísico Francisco Sánchez, s/n. Facultad de Ciencias, San Cristóbal de La Laguna, S/C de Tenerife La Laguna 38200, Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid 28029, Spain; Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna (ULL), San Cristóbal de La Laguna 38200, Tenerife, Spain.
Jazyk:	angličtina
Zdroj:	Clinics in chest medicine [Clin Chest Med] 2024 Sep; Vol. 45 (3), pp. 599-610. Date of Electronic Publication: 2024 Apr 21.
DOI:	10.1016/j.ccm.2024.03.002
Abstrakt:	Asthma is a common complex airway disease whose prediction of disease risk and most severe outcomes is crucial in clinical practice for adequate clinical management. This review discusses the latest findings in asthma genomics and current obstacles faced in moving forward to translational medicine. While genome-wide association studies have provided valuable insights into the genetic basis of asthma, there are challenges that must be addressed to improve disease prediction, such as the need for diverse representation, the functional characterization of genetic variants identified, variant selection for genetic testing, and refining prediction models using polygenic risk scores. Competing Interests: Disclosure M. Pino-Yanes reports funding from the Spanish Ministry of Science, Innovation, Spain and Universities (MCIU/AEI/10.13039/501,100,011,033), Spain. M. Pino-Yanes reports grant support CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Spain (CB/06/06/1088) and the European Regional Development Fund “ERDF A way of making Europe. All funding agencies had no role in the study design, data collection, and analysis, decision to publish, or preparation of the article. The views expressed are those of the authors and not necessarily those of the any funder. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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