Exploring WNT2 polymorphisms in comitant strabismus: A genetic association study.

Autor: Zehra Z; Translational Genomics Laboratory, Department of Biosciences, COMSATS University Islamabad, Pakistan., von Bartheld CS; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA., Agarwal AB; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA., Vasquez-Gross H; Nevada Bioinformatics Center, RRID: SCR_017802, University of Nevada, Reno, USA., Noorani Siddiqui S; Ambulatory Care Center, HMC, Doha, Qatar; Qatar University, Qatar., Azam M; Translational Genomics Laboratory, Department of Biosciences, COMSATS University Islamabad, Pakistan. Electronic address: malihazam@gmail.com., Qamar R; Pakistan Academy of Sciences, Islamabad, Pakistan; Science and Technology Sector, ICESCO, Rabat, Kingdom of Morocco. Electronic address: raheelqamar@hotmail.com.
Jazyk: angličtina
Zdroj: Gene [Gene] 2024 Nov 30; Vol. 928, pp. 148797. Date of Electronic Publication: 2024 Jul 26.
DOI: 10.1016/j.gene.2024.148797
Abstrakt: Background: Strabismus is a complex oculomotor condition characterized by a misalignment of the visual axis. The genetics of strabismus are poorly defined although a few candidate genes have been identified, among which is the WNT2 gene. Our study was designed to assess the association of single nucleotide polymorphisms (SNPs) of WNT2 in Pakistani strabismus patients.
Methods: A total of six SNPs, three intronic and three in the 3́ untranslated region, were screened in the current study. Logistic regression was performed using a dominant, recessive and additive model to determine the association of SNPs with strabismus and its clinical subtypes: esotropia and exotropia. Furthermore, haplotype analysis was performed.
Results: Regression analysis revealed an association of rs2896218, rs3779550, rs2285544 and rs4730775 with strabismus under the dominant model. When analyzed separately, rs2896218 and rs2285544 were found to be associated with both esotropia and exotropia, while rs4730775 was significantly associated only with exotropia under the dominant model. Based on clinical parameters, rs2896218, rs2285544 and rs4730775 were also found to be associated with the group of strabismus patients who were diagnosed at birth, but not in the group of patients who were diagnosed later in life. Haplotype analysis revealed that the haplotype A T T (corresponding to rs2896218, rs3779550 and rs2285544) was significantly more prevalent in the strabismus group.
Conclusion: Overall, the results of the present study suggest an association of WNT2 polymorphisms with strabismus and its subtypes in the Pakistani population, though further studies are needed to elucidate their role in strabismus etiology.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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