Comparative toxicity assessment of alternative versus legacy PFAS: Implications for two primary trophic levels in freshwater ecosystems.

Autor: Pietropoli E; Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Padua, Italy. Electronic address: edoardo.pietropoli@unipd.it., Bardhi A; Department of Veterinary Medical Sciences, University of Bologna Alma Mater Studiorum, 40064 Ozzano dell'Emilia, Bologna, Italy. Electronic address: anisa.bardhi@unibo.it., Simonato V; Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Padua, Italy. Electronic address: valentinasimonato@yahoo.it., Zanella M; Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Padua, Italy. Electronic address: martina.zanella@studenti.unipd.it., Iori S; Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Padua, Italy. Electronic address: silvia.iori@unipd.it., Barbarossa A; Department of Veterinary Medical Sciences, University of Bologna Alma Mater Studiorum, 40064 Ozzano dell'Emilia, Bologna, Italy. Electronic address: andrea.barbarossa@unibo.it., Giantin M; Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Padua, Italy. Electronic address: mery.giantin@unipd.it., Dacasto M; Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Padua, Italy. Electronic address: mauro.dacasto@unipd.it., De Liguoro M; Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Padua, Italy. Electronic address: marco.deliguoro@unipd.it., Pauletto M; Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Padua, Italy. Electronic address: marianna.pauletto@unipd.it.
Jazyk: angličtina
Zdroj: Journal of hazardous materials [J Hazard Mater] 2024 Sep 15; Vol. 477, pp. 135269. Date of Electronic Publication: 2024 Jul 20.
DOI: 10.1016/j.jhazmat.2024.135269
Abstrakt: Perfluoroalkyl substances (PFAS) are common environmental pollutants, but their toxicity framework remains elusive. This research focused on ten PFAS, evaluating their impacts on two ecotoxicologically relevant model organisms from distinct trophic levels: the crustacean Daphnia magna and the unicellular green alga Raphidocelis subcapitata. The results showed a greater sensitivity of R. subcapitata compared to D. magna. However, a 10-day follow-up to the 48 h immobilisation test in D. magna showed delayed mortality, underlining the limitations of relying on EC 50 s from standard acute toxicity tests. Among the compounds scrutinized, Perfluorodecanoic acid (PFDA) was the most toxic to R. subcapitata, succeeded by Perfluorooctane sulfonate (PFOS), Perfluorobutanoic acid (PFBA), and Perfluorononanoic acid (PFNA), with the latter being the only one to show an algicidal effect. In the same species, assessment of binary mixtures of the compounds that demonstrated high toxicity in the single evaluation revealed either additive or antagonistic interactions. Remarkably, with an EC 50 of 31 mg L -1 , the short-chain compound PFBA, tested individually, exhibited toxicity levels akin to the notorious long-chain PFOS, and its harm to freshwater ecosystems cannot be ruled out. Despite mounting toxicological evidence and escalating environmental concentrations, PFBA has received little scientific attention and regulatory stewardship. It is strongly advisable that regulators re-evaluate its use to mitigate potential risks to the environmental and human health.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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