Hypolipidemic activity of phytochemical combinations: A mechanistic review of preclinical and clinical studies.

Autor: Nechchadi H; Department of Biology, Polydisciplinary Faculty, University Sultan Moulay Slimane, 23000 Beni Mellal, Morocco. Electronic address: habiba.nechchadi@gmail.com., Nadir Y; Laboratory of Biological Engineering, Faculty of Sciences and Techniques, University Sultan Moulay Slimane, 23000 Beni Mellal, Morocco., Benhssaine K; Department of Biology, Polydisciplinary Faculty, University Sultan Moulay Slimane, 23000 Beni Mellal, Morocco., Alem C; Biochemistry of Natural Products Team, Faculty of Sciences and Techniques, Moulay Ismail University, 52000 Errachidia, Morocco., Sellam K; Biology, Environment and Health Team, Faculty of sciences and Techniques, Moulay Ismail University, 52000 Errachidia, Morocco., Boulbaroud S; Department of Biology, Polydisciplinary Faculty, University Sultan Moulay Slimane, 23000 Beni Mellal, Morocco., Berrougui H; Department of Biology, Polydisciplinary Faculty, University Sultan Moulay Slimane, 23000 Beni Mellal, Morocco., Ramchoun M; Department of Biology, Polydisciplinary Faculty, University Sultan Moulay Slimane, 23000 Beni Mellal, Morocco.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2024 Nov 30; Vol. 459, pp. 140264. Date of Electronic Publication: 2024 Jul 03.
DOI: 10.1016/j.foodchem.2024.140264
Abstrakt: Hyperlipidemia, a condition characterized by elevated levels of lipids in the blood, poses a significant risk factor for various health disorders, notably cardiovascular diseases. Phytochemical compounds are promising alternatives to the current lipid-lowering drugs, which cause many undesirable effects. Based on in vivo and clinical studies, combining phytochemicals with other phytochemicals, prebiotics, and probiotics and their encapsulation in nanoparticles is more safe and effective for managing hyperlipidemia than monotherapy. To this end, the results obtained and the mechanisms of action of these combinations were examined in detail in this review.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. All authors declare having no conflict of interest or personal relationships that could influence this work.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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