Synthesis, spectroscopic characterization and biological activities of complexes of light lanthanide ions with 3-hydroxyflavone.

Autor: Woźnicka E; Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, Rzeszow University of Technology, Powstańców Warszawy Av., 6, 35-959 Rzeszów, Poland. Electronic address: elawoz@prz.edu.pl., Zapała L; Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, Rzeszow University of Technology, Powstańców Warszawy Av., 6, 35-959 Rzeszów, Poland., Miłoś A; Doctoral School of Engineering and Technical Sciences at the Rzeszow University of Technology, Department of Biotechnology and Bioinformatics, Faculty of Chemistry, Powstańców Warszawy 6, 35-959 Rzeszów, Poland., Ciszkowicz E; Department of Biochemistry and Biotechnology, Faculty of Chemistry, Rzeszow University of Technology, Powstańców Warszawy Av., 6, 35-959 Rzeszów, Poland., Lecka-Szlachta K; Department of Biochemistry and Biotechnology, Faculty of Chemistry, Rzeszow University of Technology, Powstańców Warszawy Av., 6, 35-959 Rzeszów, Poland., Woźnicki P; Students English Division Science Club, Medical College of the University of Rzeszów, 35-959 Rzeszów, Poland., Przygórzewska A; Students English Division Science Club, Medical College of the University of Rzeszów, 35-959 Rzeszów, Poland., Kosińska-Pezda M; Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, Rzeszow University of Technology, Powstańców Warszawy Av., 6, 35-959 Rzeszów, Poland., Byczyński Ł; Department of Polymer Technology, Faculty of Chemistry, Rzeszow University of Technology, Al. Powstańców Warszawy 6, 35-959 Rzeszów, Poland.
Jazyk: angličtina
Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2024 Dec 05; Vol. 322, pp. 124870. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1016/j.saa.2024.124870
Abstrakt: New solid compounds of light lanthanide ions with 3-hydroxyflavone were synthesized in good yields (up to 85 %). The resulting complexes have been thoroughly characterized using various analytical and spectral techniques, including elemental analysis, complexometry, thermogravimetry, UV-VIS, FT-IR, 1 H NMR, 109 AgNPET LDI MS and fluorescence spectroscopy. The molecular formulas of the complexes were determined as follows: Ln(3HF) 3 , where 3HF-3-hydroxyflavone, Ln = La(III), Pr(III), Nd(III) and Ln(3HF) 3 ·nH 2 O, where n = 1 for Ln = Ce(III), Sm(III), Eu(III), and n = 2 for Gd(III). Thermogravimetric studies revealed that the water molecules in the hydrated compounds are located in the outer coordination sphere. Based on the spectral data, it was noted that lanthanide ions interacted with the 3OH and 4CO groups of 3-hydroxyflavone. The effect of lanthanide ion chelation on the excited-state intramolecular proton transfer (ESIPT) process and fluorescence emission of 3HF was investigated. It was found that coordination with metal ions can suppress the ESIPT process and enhance the fluorescence emission of 3HF. The synthesized compounds were also screened for their antibacterial activity, free radical scavenging capacity, and interaction with BSA. The results showed that the complexes exhibit higher biological activity compared to the ligand.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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