Physical performance changes as clues to late-life blood pressure changes with advanced age: the osteoporotic fractures in men study.

Autor:	Laddu DR; Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: Deepika.Laddu@arborresearch.org., Kim H; University of Illinois at Chicago, Center for Clinical and Translational Science, Biostatistics Core, 914 S. Wood Street, Chicago, IL, USA., Cawthon PM; California Pacific Medical Center Research Institute, San Francisco, California, USA; Department of Epidemiology and Biostatics, University of California, San Francisco, California, USA., LaMonte MJ; Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo - SUNY, New York, Buffalo, New York, USA., Phillips SA; Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA., Ma J; Department of Medicine, University of Illinois Chicago, 1747 W. Roosevelt Rd, Chicago, IL, USA., Stefanick ML; Department of Medicine, Stanford Prevention Research Center, School of Medicine, Stanford University, Stanford, California, USA.
Jazyk:	angličtina
Zdroj:	The journal of nutrition, health & aging [J Nutr Health Aging] 2024 Sep; Vol. 28 (9), pp. 100317. Date of Electronic Publication: 2024 Jul 26.
DOI:	10.1016/j.jnha.2024.100317
Abstrakt:	Objectives: This study examined whether changes in late-life physical performance are associated with contemporaneous changes in blood pressure (BP) in older men. Design: prospective cohort study over 7 years. Setting and Participants: Physical performance (gait speed, grip strength, chair stand performance) and clinic-measured BP at baseline and at least one follow-up (year 7 or 9) were assessed in 3,135 men aged ≥65 y enrolled in the Osteoporotic Fractures in Men Study (MrOS). Methods: Generalized estimating equation analysis of multivariable models with standardized point estimates (β [95% CI]) described longitudinal associations between physical performance and BP changes in participants overall, and stratified by baseline cardiovascular disease (CVD), antihypertensive medication use (none, ≥1), and enrollment age (<75 years; ≥75 years). Results: Overall, positive associations (z-score units) were found between each increment increase in gait speed and systolic (SBP) (0.74 [0.22, 1.26]) and grip strength (0.35 [0.04, 0.65]) or gait speed (0.55 [0.24, 0.85]) with diastolic (DBP). Better grip strength and chair stand performance over time were associated with 1.83 [0.74, 2.91] and 3.47 [0.20, 6.74] mmHg higher SBP, respectively in men with CVD at baseline (both interaction P < .05). Gait speed increases were associated with higher SBP in men without CVD (0.76 [0.21, 1.32]), antihypertensive medication non-users (0.96 [0.30, 1.62]), aged <75 years (0.73 [0.05, 1.41]) and ≥75 years (0.76 [0.06, 1.47]). Similar positive, but modest associations for DBP were observed with grip strength in men with CVD, antihypertensive medication non-users, and aged <75 years, and with gait speed in men without CVD, aged <75 years, and irrespective of antihypertensive medication use. Conclusion: In older men, better physical performance is longitudinally associated with higher BP. Mechanisms and implications of these seemingly paradoxical findings, which appears to be modified by CVD status, antihypertensive medication use, and age, requires further investigation. (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze:	MEDLINE
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