Dietary supplementation with copper nanoparticles enhances broiler performance by improving growth, immunity, digestive enzymes, and gut microbiota.

Autor:	Al-Ruwad SH; Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt., Attia AI; Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt., Abdel Monem UM; Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt., Abdel-Maksoud A; Animal and Poultry Nutrition Department, Desert Research Center, Cairo, Egypt., Thagfan FA; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Alqahtani HA; Department of Zoology, College of Science, King Saud University, Riyadh 11495, Saudi Arabia., Alkahtani AM; Department of Microbiology & Clinical Parasitology College of Medicine, King Khalid University, Abha, Saudi Arabia., Salah AS; Department of Animal Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, New Valley University, El-Kharga 72511, Egypt., Reda FM; Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt. Electronic address: fayizreda@yahoo.com.
Jazyk:	angličtina
Zdroj:	Poultry science [Poult Sci] 2024 Oct; Vol. 103 (10), pp. 104026. Date of Electronic Publication: 2024 Jun 26.
DOI:	10.1016/j.psj.2024.104026
Abstrakt:	The aim of this work is to measure the influence of copper nanoparticles (CuNPs) on growth performance, carcass traits, renal and hepatic indices, immunity, lipid profile, antioxidant status, blood minerals, digestive enzymes, and cecal microbiota in broilers. 300 unsexed one-week-old Arbor Acre broiler chicks in total were randomly assigned into 5 treatment groups of 60 chicks per eachwhich were divided into 5 replicates of 12 chicks. The 1st group (G1) was given basal diet (only); the 2nd group (G2), the 3rd group (G3), the 4th group (G4) and the 5th group (G5) were given basal diet treated with CuNPs at a rate of 5, 10, 15, and 20 mg/kg diet, respectively. The result revealed a significant improvement (P < 0.01) in performance paramters where the best values of body weight, weight gain, and feed conversion ratio were achieved at 15 mg/kg diet (CuNPs). Moreover, CuNPs supplementation significantly (P < 0.05) improved carcass traits specially carcass, dressing, giblets, and liver percentage, particularly at 15 mg/kg diet which revealed the best results. Furthermore, CuNPs supplementation at all tested levels increased the immune organ's weight (spleen and thymus). Plasma total protein and globulin were increased with CuNPs supplementation at levels 10 to 20 mg/kg diet. CuNPs supplementation (10-20 mg/kg diet) significantly improved liver and renal function by lowering the levels of AST, creatinine and uric acid. Moreover, CuNPs supplementation significantly (P < 0.05) improved lipid profile indicated by decreased the levels of cholesterol, triglyceride, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol as well as malondialdehyde (MDA). CuNP supplementation significantly improved broiler immunity indicated by increased IgA, IgM, complement (C3) and lysozyme, where CuNPs at 15 and 20 mg/kg diet revealed the best results. CuNPs supplementation increased reduced glutathione (GSH), total antioxidant capacity (TAC), and superoxide dismutase (SOD) as well as increased blood minerals (Cu, Fe, P, and Ca). Also, the digestive enzymes of broiler chicks treated with CuNPs significantly increased (P < 0.05), such as lipase, protease, and amylase enzymes. The findings revealed a significant elevation in total bacterial count (TBC) and lactic acid bacteria and significantly decreased total yeast and mold count (TYMC), E. coli, Salmonella and Coliform. In conclusion, CuNPs supplementation significantly improves performance, carcass yield, renal and hepatic indices, lipid profile, immunity, antioxidants, blood minerals, digestive enzymes, and cecal microbiota of broiler chicks. Competing Interests: DISCLOSURES The authors declare no conflicts of interest. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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