Statin intolerance and the drucebo effect.

Autor:	Mugawar B; Trinity College Dublin School of Medicine, Department of Pharmacology, Trinity Centre for Health Sciences, St James's Hospital, James's Street, Dublin 8, D08 NHY1, Ireland., Mcerlean S; Department of General Practice Dublin, Health Sciences Centre, University College Dublin School of Medicine, Belfield, Dublin 4, D04 V1W8, Ireland., O' Connor P; Trinity College Dublin School of Medicine, Department of Pharmacology, Trinity Centre for Health Sciences, St James's Hospital, James's Street, Dublin 8, D08 NHY1, Ireland.; St James's Hospital, Department of Pharmacology, St James's hospital, James's Street, Dublin 8, D08 NHY1, Ireland., Kennedy C; St James's Hospital, Department of Pharmacology, St James's hospital, James's Street, Dublin 8, D08 NHY1, Ireland.; Trinity College Dublin, HRB Clinical Research Facility Dublin, IE, St James's hospital, James's Street, Dublin 8, D08 NHY1, Ireland.
Jazyk:	angličtina
Zdroj:	QJM : monthly journal of the Association of Physicians [QJM] 2024 Jul 27. Date of Electronic Publication: 2024 Jul 27.
DOI:	10.1093/qjmed/hcae144
Abstrakt:	Hypercholesterolemia is a well-described risk factor for atherosclerotic cardiovascular disease (ASCVD). Statins remain the cornerstone of therapy. Statin intolerance (SI) particularly statin associated muscle symptoms (SAMS) and inappropriate stopping of treatment is associated with increased cardiovascular risk. A significant proportion of reported SAMS relates to expectation of side effects and can be termed the 'negative drucebo effect'. Patients should be educated about SI, the negative drucebo effect, in addition to the benefits of adherence to the therapy when first prescribed a statin. The aim of this commentary is to discuss the issue of statin intolerance, the negative drucebo effect and to suggest some interventions that may be used to address this issue. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu