Preoperatively suspected gallbladder cancer improves survival compared with incidental gallbladder cancer in pT3 patients.
| Autor: | Muszynska C; Carolina Muszynska Department of Surgery Skåne University Hospital Department of Clinical Sciences Lund University Lund SE-221 85 Sweden., Lundgren L; Department of Surgery, County Council of Östergötland, Linköping University, Linköping, Sweden.; Department of Biomedicine and Clinical Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden., Jacobsson H; Unit for Medical Statistics and Epidemiology, Clinical Studies Sweden-Forum South, Skåne University Hospital, Lund, Sweden., Sandström P; Department of Surgery, County Council of Östergötland, Linköping University, Linköping, Sweden.; Department of Biomedicine and Clinical Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden., Andersson B; Department of Surgery, Skåne University Hospital and Department of Clinical Sciences, Lund University, Lund, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society [Scand J Surg] 2024 Jul 26, pp. 14574969241263539. Date of Electronic Publication: 2024 Jul 26. |
| DOI: | 10.1177/14574969241263539 |
| Abstrakt: | Background: The aim was to compare survival for incidental gallbladder cancer (IGBC), respectively, preoperatively suspected gallbladder cancer (GBC), subjected to surgery for different pathological tumour (pT) stages and in different treatment groups in a national cohort. Methods: Data were collected and crosslinked from two national quality registers, SweLiv (2009-2019) and GallRiks (2009-2016). Survival was estimated using Kaplan-Meier analysis. The log-rank test and Cox regression analyses were used to compare groups. Results: In total, 466 IGBC patients, including 225 who only underwent simple cholecystectomy (SC), and 477 GBC patients were included. Most patients were female, with small differences in mean age between groups. In all IGBC patients compared with GBC patients, an improved 5-year overall survival in pT3 GBC undergoing surgery (GBC 13% vs all IGBC 8%, p < 0.001), was seen. GBC was shown to be an independent predictor for improved survival in pT3 patients (hazard ratio (HR): 0.6; 95% confidence interval (CI): 0.4-0.8, p < 0.001). In addition, in GBC with curative reresection compared with IGBC SC and IGBC with curative resection, an improved 5-year overall survival in pT3 GBC was shown (GBC 20% vs all IGBC 10%, p < 0.001). GBC was an independent predictor for improved survival in pT3 patients with curative resection (HR: 0.4; 95% CI: 0.3-0.7, p < 0.001). Conclusions: GBC was shown to be an independent predictor for improved survival in pT3 patients, and patients with GBC may benefit from one-stage resection. It is, therefore, reasonable to recommend that radiological suspicion of malignancy should be evaluated at a liver tumour centre to optimize patient outcomes. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article. |
| Databáze: | MEDLINE |
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