Role of Walking Energetics and Perceived Fatigability Differs by Gait Speed: The Study of Muscle, Mobility and Aging (SOMMA).

Autor:	Garcia RE; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Blackwell TL; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA., Forman DE; Department of Medicine (Divisions of Cardiology and Geriatrics), University of Pittsburgh School of Medicine, and Geriatrics, Research, Education, and Clinical Center (GRECC), Pittsburgh, Pennsylvania, USA., Coen PM; Translational Research Institute for Metabolism and Diabetes, Advent Health, Orlando, Florida, USA., Nicklas BJ; Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Qiao YS; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA., Cawthon PM; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA., Toledo FGS; Department of Medicine (Divisions of Endocrinology and Metabolism), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Goodpaster BH; Translational Research Institute for Metabolism and Diabetes, Advent Health, Orlando, Florida, USA., Cummings SR; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA., Newman AB; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Glynn NW; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2024 Sep 01; Vol. 79 (9).
DOI:	10.1093/gerona/glae187
Abstrakt:	Background: Slower gait speed may be driven by greater energy deficits and fatigability among older adults. We examined associations of walking energetics and perceived physical fatigability with gait speed among slower and faster walkers. Additionally, we used statistical mediation to examine the role of fatigability in the associations of walking energetics and gait speed using the Study of Muscle, Mobility and Aging (SOMMA). Methods: Perceived physical fatigability was assessed using the Pittsburgh Fatigability Scale (PFS) Physical score (range 0-50, higher = greater). A 3-phase cardiopulmonary exercise treadmill test collected peak oxygen consumption (VO2peak, mL/kg/min), energetic cost of walking (ECW, mL/kg/m), and cost-capacity ratio (VO2/VO2peak*100, %). Slower (<1.01 m/s) versus faster (≥1.01 m/s) walkers were classified using median 4-m gait speed. Linear regressions and statistical mediation analyses were conducted. Results: Slower walkers had lower VO2peak, higher ECW at preferred walking speed (PWS), and greater PFS Physical score compared to faster walkers (all p < .05; N = 849). One standard deviation (1-SD) higher VO2peak was associated with 0.1 m/s faster gait speed, while 1-SD higher ECW PWS, cost-capacity ratio at PWS and slow walking speed (SWS), and PFS Physical score were associated with 0.02-0.23 m/s slower gait speed. PFS Physical score was a significant statistical mediator in the associations between VO2peak (15.2%), SWS cost-capacity ratio (15.9%), and ECW PWS (10.7%) with gait speed and was stronger among slower walkers. Conclusions: Slower walkers may be more influenced by perceptions of fatigue in addition to walking energetics. Our work highlights the importance of targeting both energetics and perceived fatigability to prevent mobility decline. (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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