Long-Lasting Enhanced Cytokine Responses Following SARS-CoV-2 BNT162b2 mRNA Vaccination.

Autor:	Cabău G; Department of Medical Genetics, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Badii M; Department of Medical Genetics, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.; Department of Internal Medicine, Radboud UMC, 6525 GA Nijmegen, The Netherlands., Mirea AM; Department of Medical Genetics, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Gaal OI; Department of Medical Genetics, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.; Department of Internal Medicine, Radboud UMC, 6525 GA Nijmegen, The Netherlands., van Emst L; Department of Internal Medicine, Radboud UMC, 6525 GA Nijmegen, The Netherlands., Popp RA; Department of Medical Genetics, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Crișan TO; Department of Medical Genetics, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.; Department of Internal Medicine, Radboud UMC, 6525 GA Nijmegen, The Netherlands., Joosten LAB; Department of Medical Genetics, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.; Department of Internal Medicine, Radboud UMC, 6525 GA Nijmegen, The Netherlands.
Jazyk:	angličtina
Zdroj:	Vaccines [Vaccines (Basel)] 2024 Jul 03; Vol. 12 (7). Date of Electronic Publication: 2024 Jul 03.
DOI:	10.3390/vaccines12070736
Abstrakt:	The mRNA vaccine against COVID-19 protects against severe disease by the induction of robust humoral and cellular responses. Recent studies have shown the capacity of some vaccines to induce enduring non-specific innate immune responses by the induction of trained immunity, augmenting protection against unrelated pathogens. This study aimed to assess whether the mRNA vaccine BNT162b2 can induce lasting non-specific immune responses in myeloid cells following a three-dose vaccination scheme. In a sample size consisting of 20 healthy individuals from Romania, we assessed inflammatory proteins using the Olink ® Target 96 Inflammation panel, as well as ex vivo cytokine responses following stimulations with unrelated PRR ligands. We assessed the vaccine-induced non-specific systemic inflammation and functional adaptations of myeloid cells. Our results revealed the induction of a stimulus- and cytokine-dependent innate immune memory phenotype that became apparent after the booster dose and was maintained eight months later in the absence of systemic inflammation.
Databáze:	MEDLINE
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