Prospective Audit and Feedback for Antimicrobial Treatment of Patients Receiving Renal Replacement Therapy in Community-Based University Hospitals: A before-and-after Study.

Autor: Park N; Department of Pharmacy, Ewha Womans University Mokdong Hospital, Seoul 07985, Republic of Korea.; College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea., Bae J; Division of Infectious Diseases, Department of Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul 07985, Republic of Korea., Nam SY; Department of Pharmacy, Ewha Womans University Mokdong Hospital, Seoul 07985, Republic of Korea., Bae JY; Division of Infectious Diseases, Department of Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul 07985, Republic of Korea., Jun KI; Division of Infectious Diseases, Department of Internal Medicine, Ewha Womans University Seoul Hospital, Seoul 07804, Republic of Korea., Kim JH; Division of Infectious Diseases, Department of Internal Medicine, Ewha Womans University Seoul Hospital, Seoul 07804, Republic of Korea., Kim CJ; Division of Infectious Diseases, Department of Internal Medicine, Ewha Womans University Seoul Hospital, Seoul 07804, Republic of Korea., Kim K; Department of Pharmacy, Ewha Womans University Seoul Hospital, Seoul 07804, Republic of Korea., Kim SA; Department of Pharmacy, Ewha Womans University Mokdong Hospital, Seoul 07985, Republic of Korea., Choi HJ; Division of Infectious Diseases, Department of Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul 07985, Republic of Korea., Rhie SJ; College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.
Jazyk: angličtina
Zdroj: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 Jun 28; Vol. 17 (7). Date of Electronic Publication: 2024 Jun 28.
DOI: 10.3390/ph17070854
Abstrakt: In South Korea, because of manpower and budgetary limitations, antimicrobial stewardship programs have relied on preauthorization. This study analyzed the impact of a prospective audit and feedback (PAF) program targeting inpatients undergoing intermittent hemodialysis or continuous renal replacement therapy, which was implemented at two community-based university hospitals. During three years of PAF, 27,906 antimicrobial prescriptions were reviewed, with 622 (2.2%) interventions. The mean incidence density per 1000 patient days of multidrug-resistant organisms, except for carbapenem-resistant Acinetobacter baumannii , decreased in the study population, whereas it increased among inpatients. Multivariable Poisson regression analysis revealed that after PAF, the incidences of vancomycin-resistant Enterococcus and mortality decreased (incidence risk ratio, 95% confidence interval: 0.53, 0.31-0.93 and 0.70, 0.55-0.90, respectively). Notably, after PAF, incorrect antimicrobial dosing rates significantly decreased (tau -0.244; p = 0.02). However, the incidences of other multidrug-resistant organisms, Clostridioides difficile , length of stay, and readmission did not significantly change. This study shows that in patients undergoing intermittent hemodialysis or continuous renal replacement, targeted PAF can significantly reduce multidrug-resistant organism rates and all-cause hospital mortality, despite limited resources. Furthermore, it can improve antimicrobial dosage accuracy.
Competing Interests: The authors declare no conflicts of interest.
Databáze: MEDLINE
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