| Autor: |
Dávid CZ; Department of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary., Kúsz N; Department of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary., Agbadua OG; Department of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary., Berkecz R; Institute of Pharmaceutical Analysis, University of Szeged, 6720 Szeged, Hungary., Kincses A; Department of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary.; HUN-REN-USZ Biologically Active Natural Products Research Group, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary., Spengler G; Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, Hungary., Hunyadi A; Department of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary.; HUN-REN-USZ Biologically Active Natural Products Research Group, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary., Hohmann J; Department of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary.; HUN-REN-USZ Biologically Active Natural Products Research Group, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary., Vasas A; Department of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary.; HUN-REN-USZ Biologically Active Natural Products Research Group, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary. |
| Abstrakt: |
Phenolic compounds are the main special metabolites of Cyperaceae species from phytochemical, pharmacological, and chemotaxonomical points of view. The present study focused on the isolation, structure determination, and pharmacological investigation of constituents from Carex praecox . Twenty-six compounds, including lignans, stilbenes, flavonoids, megastigmanes, chromenes, and phenylpropanoids, were identified from the methanol extract of the plant. Five of these compounds, namely, carexines A-E, are previously undescribed natural products. All compounds were isolated for the first time from C. praecox . The ACE-inhibitory activity of seven stilbenoid compounds was tested, and (-)-hopeaphenol proved to be the most active (IC 50 7.7 ± 0.9 μM). The enzyme-kinetic studies revealed a mixed-type inhibition; therefore, domain-specific studies were also conducted. The in silico docking of (-)-hopeaphenol to the ACE affirmed some favorable interactions. In addition, the antiproliferative and antibacterial effects of some compounds were also evaluated. |
