| Autor: |
Legonkova OA; Vishnevsky National Medical Research Center of Surgery, Ministry of Health of the Russian Federation, Bolshaya Serpukhovskaya Street 27, 117997 Moscow, Russia., Sultanova NO; Vishnevsky National Medical Research Center of Surgery, Ministry of Health of the Russian Federation, Bolshaya Serpukhovskaya Street 27, 117997 Moscow, Russia., Stafford VV; Vishnevsky National Medical Research Center of Surgery, Ministry of Health of the Russian Federation, Bolshaya Serpukhovskaya Street 27, 117997 Moscow, Russia.; Scriabin and Kovalenko Federal Scientific Center, Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Ryazansky Prospekt Street 24. b.1, 109428 Moscow, Russia., Zavitaeva AA; Vishnevsky National Medical Research Center of Surgery, Ministry of Health of the Russian Federation, Bolshaya Serpukhovskaya Street 27, 117997 Moscow, Russia., Kopitsyn DS; Department of Physical and Colloid Chemistry, National University of Oil and Gas 'Gubkin University', Leninsky Prospekt 65, 119991 Moscow, Russia., Tolboeva ER; Vishnevsky National Medical Research Center of Surgery, Ministry of Health of the Russian Federation, Bolshaya Serpukhovskaya Street 27, 117997 Moscow, Russia., Mahmydov AM; Vishnevsky National Medical Research Center of Surgery, Ministry of Health of the Russian Federation, Bolshaya Serpukhovskaya Street 27, 117997 Moscow, Russia., Vinokurov VA; Department of Physical and Colloid Chemistry, National University of Oil and Gas 'Gubkin University', Leninsky Prospekt 65, 119991 Moscow, Russia., Davydova GA; Federal State Institution of Science, Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences (ITEB RAS), Institutskaya Street 3, 142290 Pushchino, Moscow Region, Russia., Svishcheva NB; Vishnevsky National Medical Research Center of Surgery, Ministry of Health of the Russian Federation, Bolshaya Serpukhovskaya Street 27, 117997 Moscow, Russia., Barbaro K; Istituto Zooprofilattico Sperimentale Lazio e Toscana 'M. Aleandri', Via Appia Nuova 1411, 00178 Rome, Italy., Rau JV; Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche, ISM-CNR, Via del Fosso del Cavaliere 100, 00133 Rome, Italy.; Department of Analytical, Physical and Colloid Chemistry, Institute of Pharmacy, Sechenov First Moscow State Medical University, Trubetskaya 8, Build. 2, 119048 Moscow, Russia. |
| Abstrakt: |
In the past, polyacrylamide hydrogel was a popular choice for breast augmentation filler, and many women underwent mammoplasty with this gel. However, due to frequent complications, the use of polyacrylamide hydrogel in mammoplasty has been banned. Despite this ban, patients experiencing complications still seek medical treatment. The aim of this study was to investigate the fate of the polymer over a defined implantation period. Biopsies of breast implants were obtained from patients with 23 and 27 years of post-mammoplasty. These biopsies were meticulously purified from biological impurities and subjected to analysis using IR spectrometry, liquid chromatography-mass spectrometry, gas chromatography, and differential scanning calorimetry. The findings revealed the presence of polyacrylamide hydrogel residues, along with degradation products, within the infected material. Notably, the low-molecular-weight degradation products revealed via gas chromatography are aggressive and toxic substances capable of inducing chronic inflammation. This study sheds light on the long-term consequences of polyacrylamide hydrogel implantation, highlighting the persistence of harmful degradation products and their role in exacerbating patient complications. |
