Effects of Short-Term Gluten-Free Diet on Cardiovascular Biomarkers and Quality of Life in Healthy Individuals: A Prospective Interventional Study.

Autor:	Lange S; Department of Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany., Tsohataridis S; Department of Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany., Boland N; Department of Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany., Ngo L; Department of Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany., Hahad O; Department of Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 55131 Mainz, Germany., Münzel T; Department of Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany., Wild P; Department of Preventive Cardiology and Medical Prevention, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany., Daiber A; Department of Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany., Schuppan D; Institute of Translational Immunology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany., Lurz P; Department of Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany., Keppeler K; Department of Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany., Steven S; Department of Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.; Department of Cardiology, Goethe University Frankfurt, 60596 Main, Germany.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2024 Jul 13; Vol. 16 (14). Date of Electronic Publication: 2024 Jul 13.
DOI:	10.3390/nu16142265
Abstrakt:	Introduction: The exposome concept includes nutrition as it significantly influences human health, impacting the onset and progression of diseases. Gluten-containing wheat products are an essential source of energy for the world's population. However, a rising number of non-celiac healthy individuals tend to reduce or completely avoid gluten-containing cereals for health reasons. Aim and Methods: This prospective interventional human study aimed to investigate whether short-term gluten avoidance improves cardiovascular endpoints and quality of life (QoL) in healthy volunteers. A cohort of 27 participants followed a strict gluten-free diet (GFD) for four weeks. Endothelial function measured by flow-mediated vasodilation (FMD), blood testing, plasma proteomics (Olink ® ) and QoL as measured by the World Health Organisation Quality-of-Life (WHOQOL) survey were investigated. Results: GFD resulted in decreased leucocyte count and C-reactive protein levels along with a trend of reduced inflammation biomarkers determined by plasma proteomics. A positive trend indicated improvement in FMD, whereas other cardiovascular endpoints remained unchanged. In addition, no improvement in QoL was observed. Conclusion: In healthy individuals, a short-term GFD demonstrated anti-inflammatory effects but did not result in overall cardiovascular improvement or enhanced quality of life.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu