| Autor: |
Goluch Z; Department of Food Technology and Nutrition, Wroclaw University of Economics and Business, Komandorska 118/120, 53-345 Wrocław, Poland., Wierzbicka-Rucińska A; Department of Clinical Biochemistry, Radioimmunology and Experimental Medicine, Children's Memorial Health Institute, 04-730 Warsaw, Poland., Książek E; Department of Agricultural Engineering and Quality Analysis, Wrocław University of Economics and Business, Komandorska 118/120, 53-345 Wrocław, Poland. |
| Jazyk: |
angličtina |
| Zdroj: |
Nutrients [Nutrients] 2024 Jul 12; Vol. 16 (14). Date of Electronic Publication: 2024 Jul 12. |
| DOI: |
10.3390/nu16142247 |
| Abstrakt: |
Gilbert syndrome is the most common hyperbilirubinemia, associated with a mutation in the UGT1A1 bilirubin gene, which produces an enzyme that conjugates bilirubin with glucuronic acid. Episodes of jaundice occurring in GS negatively affect patients' quality of life. This systematic review aimed to analyze clinical studies regarding nutrition in people with GS. The study followed the PRISMA guidelines and utilized the Ebsco, Embase, Cochrane, PubMed, Scopus, and Web of Science databases to search clinical trials focused on diet/nutrition in GS (1963-2023 years). The methodological quality of selected studies was assessed using the Jadad scale. As a result, 19 studies met the inclusion criteria. The research mainly focused on the impact of caloric restriction, consumption of various diet variants, and vegetables and fruits on hyperbilirubinemia and metabolic health. A nutritional intervention consisting of not applying excessive calorie restrictions and consuming fats and biologically active compounds in vegetables and fruits ( Cruciferae , Apiaceous , Rutaceae ) may prevent the occurrence of jaundice episodes. It is justified to conduct further research on detecting such compounds in food, which, by influencing the expression of the UGT liver enzyme gene, could contribute to regulating bilirubin concentration in the blood of people with GS. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
