| Autor: |
Fruh V; Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA., Babalola T; Program in Public Health, Department of Family, Population, & Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Sears C; Division of Environmental Medicine, Department of Medicine, University of Louisville, Louisville, KY 40292, USA., Wellenius GA; Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA., Webster TF; Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA., Mann KK; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3A 0G4, Canada., Harrington J; Center for Analytical Science, Research Triangle Institute, Research Triangle Park, NC 27709, USA., Tjønneland A; Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.; Department of Public Health, University of Copenhagen, 1353 Copenhagen, Denmark., Raaschou-Nielsen O; Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.; Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark., Claus Henn B; Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA., Meliker JR; Program in Public Health, Department of Family, Population, & Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA. |
| Abstrakt: |
Background: Diet is known to impact cardiovascular disease (CVD) risk, but evidence for the essential minerals of magnesium (Mg), calcium (Ca), and potassium (K) is inconsistent. Methods: We conducted a case-cohort study within a non-smoking subgroup of the Danish Diet, Cancer and Health cohort, a prospective study of 50-64-year-olds recruited between 1993-1997. We identified incident heart failure (HF), acute myocardial infarction (AMI) and stroke cases through 2015 with an 1135-member subcohort. We measured the dietary intake of minerals, also known as elements, and calculated a combined dietary intake (CDI) score based on joint Ca, Mg and K intakes (mg/d) from Food Frequency Questionnaires. We estimated adjusted hazard ratios (HRs) with Cox proportional hazard models. Results: Most HRs examining associations between CDI score and CVD were null. However, the third quartile of CDI was associated with a lower risk for heart failure (HR: 0.89; 95% CI: 0.67, 1.17), AMI (HR: 0.79; 95% CI: 0.60, 1.04), and stroke (HR: 0.63; 95% CI: 0.44, 0.88). Conclusions: We did not find consistent evidence to suggest that higher levels of essential minerals are associated with incident HF, AMI, and stroke, though results suggest a potential U-shaped relationship between select minerals and CVD outcomes. |
