| Autor: |
Kawasaki E; Diabetes, Thyroid, and Endocrine Center, Shin-Koga Hospital, Kurume 830-8577, Japan., Jinnouchi H; Department of Internal Medicine, Jinnouchi Hospital Diabetes Care Center, Kumamoto 862-0976, Japan., Maeda Y; Minami Diabetes Clinical Research Center, Clinic Masae Minami, Fukuoka 815-0071, Japan., Okada A; Okada Clinic, Fukuoka 812-0053, Japan., Kawai K; Kawai Clinic, Ibaraki 305-0812, Japan. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of molecular sciences [Int J Mol Sci] 2024 Jul 11; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 11. |
| DOI: |
10.3390/ijms25147618 |
| Abstrakt: |
The 3 Screen ICA ELISA is a novel assay capable of simultaneously measuring autoantibodies to glutamic acid decarboxylase (GADA), insulinoma-associated antigen-2 (IA-2A), and zinc transporter 8 (ZnT8A), making it a valuable tool for screening type 1 diabetes. Despite its advantages, it cannot specify which individual autoantibodies are positive or negative. This study aimed to estimate individual positive autoantibodies based on the 3 Screen ICA titer. Six hundred seventeen patients with type 1 diabetes, simultaneously measured for 3 Screen ICA and three individual autoantibodies, were divided into five groups based on their 3 Screen ICA titer. The sensitivities and contribution rates of the individual autoantibodies were then examined. The study had a cross-sectional design. Sixty-nine percent (424 of 617) of patients with type 1 diabetes had 3 Screen ICA titers exceeding the 99th percentile cut-off level (20 index). The prevalence of GADA ranged from 80% to 100% in patients with a 3 Screen ICA over 30 index and 97% of patients with a 3 Screen ICA ≥300 index. Furthermore, the prevalence of all individual autoantibodies being positive was 0% for ≤80 index and as high as 92% for ≥300 index. Significant associations were observed in specific titer groups: the 20-29.9 index group when all the individual autoantibodies were negative, the 30-79.9 index group when positive for GADA alone or IA-2A alone, the 30-299.9 index group when positive for ZnT8A alone, the 80-299.9 index group when positive for both IA-2A and ZnT8A, the 300-499.9 index group when positive for both GADA and ZnT8A, and the ≥300 index group when positive for all individual autoantibodies. These results suggest that the 3 Screen ICA titer may be helpful in estimating individual positive autoantibodies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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