| Autor: |
Iuso D; University of Teramo, Department of Veterinary Medicine, 64100 Teramo, Italy., Guilliaumet J; University Grenoble-Alpes, CNRS UMR 5309, INSERM U1209, Institute for Advanced Biosciences, 38706 La Tronche, France., Schlattner U; University Grenoble-Alpes, INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics (LBFA), 38058 Grenoble, France.; Institut Universitaire de France, 75231 Paris, France., Khochbin S; University Grenoble-Alpes, CNRS UMR 5309, INSERM U1209, Institute for Advanced Biosciences, 38706 La Tronche, France. |
| Abstrakt: |
Nucleoside diphosphate (NDP) kinases 1 and 2 (NME1/2) are well-characterized enzymes known for their NDP kinase activity. Recently, these enzymes have been shown by independent studies to bind coenzyme A (CoA) or acyl-CoA. These findings suggest a hitherto unknown role for NME1/2 in the regulation of CoA/acyl-CoA-dependent metabolic pathways, in tight correlation with the cellular NTP/NDP ratio. Accordingly, the regulation of NME1/2 functions by CoA/acyl-CoA binding has been described, and additionally, NME1/2 have been shown to control the cellular pathways consuming acetyl-CoA, such as histone acetylation and fatty acid synthesis. NME1/2-controlled histone acetylation in turn mediates an important transcriptional response to metabolic changes, such as those induced following a high-fat diet (HFD). This review discusses the CoA/acyl-CoA-dependent NME1/2 activities and proposes that these enzymes be considered as the first identified carriers of CoA/short-chain acyl-CoAs. |
