| Autor: |
Baneu P; Doctoral School, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania.; Department of Cardiology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.; Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania., Văcărescu C; Department of Cardiology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.; Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.; Research Center of the Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania., Drăgan SR; Department of Cardiology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.; Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.; Research Center of the Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania., Cirin L; Doctoral School, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Lazăr-Höcher AI; Doctoral School, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania.; Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania., Cozgarea A; Doctoral School, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania.; County Clinical Emergency Hospital of Sibiu, 550245 Sibiu, Romania., Faur-Grigori AA; Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania., Crișan S; Department of Cardiology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.; Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.; Research Center of the Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania., Gaiță D; Department of Cardiology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.; Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.; Research Center of the Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania., Luca CT; Department of Cardiology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.; Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.; Research Center of the Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania., Cozma D; Department of Cardiology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.; Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.; Research Center of the Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania. |
| Abstrakt: |
Given the widespread occurrence of insulin resistance, a key factor in metabolic syndrome and a distinct condition altogether, there is a clear need for effective, surrogate markers. The triglyceride-to-high-density lipoprotein (TG/HDL) ratio stands out as a viable option, indicative of changes in lipid metabolism associated with insulin resistance, offering a cost-effective and straightforward alternative to traditional, more complex biomarkers. This review, in line with PRISMA guidelines, assesses the TG/HDL ratio's potential as an indirect indicator of insulin resistance. Analysing 32 studies over 20 years, involving 49,782 participants of diverse ethnic backgrounds, including adults and children, this review primarily uses a cross-sectional analysis with the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) to gauge insulin resistance. It reveals the TG/HDL ratio's varied predictive power across ethnicities and sexes, with specific thresholds providing greater accuracy for Caucasians, Asians, and Hispanics over African Americans and for men over women. Valid across different weights and ages, for adults and children, it suggests average cutoffs of 2.53 for women and 2.8 for men. The analysis supports the TG/HDL ratio as a simple, accessible marker for insulin resistance, though it advises further research on tailored cutoffs reflecting ethnic and gender differences. |
