Helmet Radio Frequency Phased Array Applicators Enhance Thermal Magnetic Resonance of Brain Tumors.

Autor: Rahimi F; Berlin Ultrahigh Field Facility, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; FG Theoretische Elektrotechnik, Technical University of Berlin, 10587 Berlin, Germany., Nurzed B; Berlin Ultrahigh Field Facility, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Technische Universität Berlin, Chair of Medical Engineering, 10587 Berlin, Germany.; Berliner Hochschule für Technik, 13353 Berlin, Germany., Eigentler TW; Technische Universität Berlin, Chair of Medical Engineering, 10587 Berlin, Germany., Berangi M; Berlin Ultrahigh Field Facility, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; MRI.TOOLS GmbH, 13125 Berlin, Germany., Oberacker E; Berlin Ultrahigh Field Facility, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany., Kuehne A; MRI.TOOLS GmbH, 13125 Berlin, Germany., Ghadjar P; Department Radiation Oncology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany., Millward JM; Berlin Ultrahigh Field Facility, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Experimental and Clinical Research Center, Joint Cooperation between Charité Unversitätsmedizin and the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany., Schuhmann R; FG Theoretische Elektrotechnik, Technical University of Berlin, 10587 Berlin, Germany., Niendorf T; Berlin Ultrahigh Field Facility, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; MRI.TOOLS GmbH, 13125 Berlin, Germany.; Experimental and Clinical Research Center, Joint Cooperation between Charité Unversitätsmedizin and the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.
Jazyk: angličtina
Zdroj: Bioengineering (Basel, Switzerland) [Bioengineering (Basel)] 2024 Jul 19; Vol. 11 (7). Date of Electronic Publication: 2024 Jul 19.
DOI: 10.3390/bioengineering11070733
Abstrakt: Thermal Magnetic Resonance (ThermalMR) integrates Magnetic Resonance Imaging (MRI) diagnostics and targeted radio-frequency (RF) heating in a single theranostic device. The requirements for MRI (magnetic field) and targeted RF heating (electric field) govern the design of ThermalMR applicators. We hypothesize that helmet RF applicators (HPA) improve the efficacy of ThermalMR of brain tumors versus an annular phased RF array (APA). An HPA was designed using eight broadband self-grounded bow-tie (SGBT) antennae plus two SGBTs placed on top of the head. An APA of 10 equally spaced SGBTs was used as a reference. Electromagnetic field (EMF) simulations were performed for a test object (phantom) and a human head model. For a clinical scenario, the head model was modified with a tumor volume obtained from a patient with glioblastoma multiforme. To assess performance, we introduced multi-target evaluation (MTE) to ensure whole-brain slice accessibility. We implemented time multiplexed vector field shaping to optimize RF excitation. Our EMF and temperature simulations demonstrate that the HPA improves performance criteria critical to MRI and enhances targeted RF and temperature focusing versus the APA. Our findings are a foundation for the experimental implementation and application of a HPA en route to ThermalMR of brain tumors.
Databáze: MEDLINE
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