| Autor: |
Shee Da En Z; Centre for Manufacturing and Environmental Sustainability (CMES), Faculty of Engineering and Technology, Multimedia University, Ayer Keroh 75450, Malaysia., Mhd Noor EE; Centre for Manufacturing and Environmental Sustainability (CMES), Faculty of Engineering and Technology, Multimedia University, Ayer Keroh 75450, Malaysia., Ahmed Kayani A; Functional Materials and Microsystems Research Group, School of Engineering, RMIT University, Melbourne, VIC 3001, Australia., Hussin MH; Materials Technology Research Group (MaTReC), School of Chemical Sciences, Universiti Sains Malaysia, Minden 11800, Malaysia., Farrukh Baig M; Centre for Manufacturing and Environmental Sustainability (CMES), Faculty of Engineering and Technology, Multimedia University, Ayer Keroh 75450, Malaysia. |
| Abstrakt: |
This study employs electrochemical impedance spectroscopy (EIS) to probe the behavior of Tau-441 protein, a key component implicated in Alzheimer's disease. Through meticulous experimentation and analysis, the impedance of Tau-441 protein suspension revealed a conductivity peak value of 1.02 S/m. The study demonstrates a high level of specificity and selectivity, particularly within the challenging nanomolar concentration range. Additionally, the EIS method enabled the prediction of Tau-441 protein's dielectrophoresis (DEP) response and the determination of the associated frequency range of 1 kHz to 1 MHz. These findings contribute to advancing our understanding of the molecular intricacies surrounding Tau-441 and hold promise for unraveling implications related to Alzheimer's disease. This study establishes a robust foundation for future research on neurodegenerative disease and biosciences, offering valuable insights into the electrochemical dynamics of Tau-441 protein. |
