| Autor: |
de Albuquerque LL; School of Health and Applied Human Sciences, University of North Carolina Wilmington, Wilmington, NC 28403, USA., Pantovic M; Health and Human Performance Department, Utah Tech University, St. George, UT 84770, USA., Wilkins EW; Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA., Morris D; School of Medicine, University of Nevada-Las Vegas, Las Vegas, NV 89154, USA., Clingo M; School of Medicine, University of Nevada-Las Vegas, Las Vegas, NV 89154, USA., Boss S; School of Life Sciences, University of Nevada-Las Vegas, Las Vegas, NV 89154, USA., Riley ZA; Department of Kinesiology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA., Poston B; Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA. |
| Abstrakt: |
Short-interval intracortical inhibition (SICI) is a common paired-pulse transcranial magnetic stimulation (TMS) measure used to assess primary motor cortex (M1) interneuron activity in healthy populations and in neurological disorders. Many of the parameters of TMS stimulation to most accurately measure SICI have been determined. However, one TMS parameter that has not been investigated is the time between SICI trials (termed inter-trial interval; ITI). This is despite a series of single-pulse TMS studies which have reported that motor evoked potential (MEP) amplitude were suppressed for short, but not long ITIs in approximately the initial ten trials of a TMS block of 20-30 trials. The primary purpose was to examine the effects of ITI on the quantification of SICI at rest. A total of 23 healthy adults completed an experimental session that included four SICI trial blocks. Each block utilized a different ITI (4, 6, 8, and 10 s) and was comprised of a total of 26 SICI trials divided into three epochs. ANOVA revealed that the main effects for ITI and epoch as well as their interaction were all non-statistically significant for SICI. We conclude that the shorter (4-6 s) ITIs used in studies investigating SICI should not alter the interpretation of M1 activity, while having the advantages of being more comfortable to participants and reducing the experimental time needed to evaluate perform single and paired-pulse TMS experiments. |
