| Autor: |
Sannes AC; Faculty of Health Science, Oslo Metropolitan University, 0890 Oslo, Norway.; Department for Research and Development in Mental Health, Akershus University Hospital, 1474 Lørenskog, Norway., Ghani U; Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland 1060, New Zealand.; Faculty of Health & Environmental Sciences, Health & Rehabilitation Research Institute, AUT University, Auckland 1010, New Zealand., Niazi IK; Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland 1060, New Zealand.; Faculty of Health & Environmental Sciences, Health & Rehabilitation Research Institute, AUT University, Auckland 1010, New Zealand.; Faculty of Medicine, Aalborg University, 9260 Aalborg, Denmark., Moberget T; Faculty of Health Sciences, Kristiania University College, 0107 Oslo, Norway.; Centre for Precision Psychiatry, University of Oslo, 0373 Oslo, Norway., Jonassen R; Faculty of Health Science, Oslo Metropolitan University, 0890 Oslo, Norway., Haavik H; Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland 1060, New Zealand., Gjerstad J; Department for Research and Development in Mental Health, Akershus University Hospital, 1474 Lørenskog, Norway.; Faculty of Health Sciences, Kristiania University College, 0107 Oslo, Norway. |
| Abstrakt: |
Despite most episodes of low back pain (LBP) being short-lasting, some transition into persistent long-lasting problems. Hence, the need for a deeper understanding of the physiological mechanisms of this is pertinent. Therefore, the aims of the present study are (1) to map pain-induced changes in brain activity and blood gene expression associated with persistent LBP, and (2) to explore whether these brain and gene expression signatures show promise as predictive biomarkers for the development of persistent LBP. The participants will be allocated into three different pain groups (no pain, mild short-lasting, or moderate long-term). One in-person visit, where two blood samples will be collected and sent for RNA sequencing, along with resting 64-channel electro-encephalography measurements before, during, and after a cold pressor test, will be conducted. Thereafter, follow-up questionnaires will be distributed at 2 weeks, 3 months, and 6 months. Recruitment will start during the second quarter of 2024, with expected completion by the last quarter of 2024. The results are expected to provide insight into the relationship between central nervous system activity, gene expression profiles, and LBP. If successful, this study has the potential to provide physiological indicators that are sensitive to the transition from mild, short-term LBP to more problematic, long-term LBP. |
