Targeting Hepatic Cancer Stem Cells (CSCs) and Related Drug Resistance by Small Interfering RNA (siRNA).

Autor: Jasim SA; Medical Laboratory Techniques Department, Al-maarif University College, Anbar, Iraq. Saad.a.j.anbar@gmail.com., Salahdin OD; Biology Department, College of Education for pure science, University Of Anbar, Anbar, Iraq. Omer9922ff@uoanbar.edu.iq., Malathi H; Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to be University, Bangalore, Karnataka, India., Sharma N; Chandigarh Pharmacy College, Chandigarh group of Colleges, Jhanjeri, 140307, Mohali, Punjab, India., Rab SO; Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia., Aminov Z; Department of Public Health and Healthcare management, Samarkand State Medical University, 18 Amir Temur Street, Samarkand, Uzbekistan., Pramanik A; School of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, India., Mohammed IH; College of nursing, National University of Science and Technology, Nasiriyah, Dhi Qar, Iraq., Jawad MA; Department of Medical Laboratories Technology, Al-Nisour University College, Baghdad, Iraq., Gabel BC; Medical laboratory technique college, the Islamic University, Najaf, Iraq.; Medical laboratory technique college, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.; Medical laboratory technique college, the Islamic University of Babylon, Babylon, Iraq.
Jazyk: angličtina
Zdroj: Cell biochemistry and biophysics [Cell Biochem Biophys] 2024 Dec; Vol. 82 (4), pp. 3031-3051. Date of Electronic Publication: 2024 Jul 26.
DOI: 10.1007/s12013-024-01423-5
Abstrakt: Tumor recurrence after curative therapy and hepatocellular carcinoma (HCC) cells' resistance to conventional therapies is the reasons for the worse clinical results of HCC patients. A tiny population of cancer cells with a strong potential for self-renewal, differentiation, and tumorigenesis has been identified as cancer stem cells (CSCs). The discovery of CSC surface markers and the separation of CSC subpopulations from HCC cells have been made possible by recent developments in the study of hepatic (liver) CSCs. Hepatic CSC surface markers include epithelial cell adhesion molecules (EpCAM), CD133, CD90, CD13, CD44, OV-6, ALDH, and K19. CSCs have a significant influence on the development of cancer, invasiveness, self-renewal, metastasis, and drug resistance in HCC, and thus provide a therapeutic chance to treat HCC and avoid its recurrence. Therefore, it is essential to develop treatment approaches that specifically and effectively target hepatic stem cells. Given this, one potential treatment approach is to use particular small interfering RNA (siRNA) to target CSC, disrupting their behavior and microenvironment as well as changing their epigenetic state. The characteristics of CSCs in HCC are outlined in this study, along with new treatment approaches based on siRNA that may be used to target hepatic CSCs and overcome HCC resistance to traditional therapies.
Competing Interests: Compliance with Ethical Standards Conflict of Interest The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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