Exploring the potential of tocopherols: mechanisms of action and perspectives in the prevention and treatment of breast cancer.

Autor: Nava-Tapia DA; Facultad de Ciencias Químico Biológicas, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N., 39090, Chilpancingo, Guerrero, Mexico., Román-Justo NY; Facultad de Ciencias Químico Biológicas, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N., 39090, Chilpancingo, Guerrero, Mexico., Cuenca-Rojo A; Facultad de Ciencias Químico Biológicas, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N., 39090, Chilpancingo, Guerrero, Mexico., Guerrero-Rivera LG; Facultad de Ciencias Químico Biológicas, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N., 39090, Chilpancingo, Guerrero, Mexico., Patrón-Guerrero A; Facultad de Ciencias Químico Biológicas, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N., 39090, Chilpancingo, Guerrero, Mexico., Poblete-Cruz RI; Facultad de Ciencias Químico Biológicas, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N., 39090, Chilpancingo, Guerrero, Mexico., Zacapala-Gómez AE; Facultad de Ciencias Químico Biológicas, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N., 39090, Chilpancingo, Guerrero, Mexico., Sotelo-Leyva C; Facultad de Ciencias Químico Biológicas, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N., 39090, Chilpancingo, Guerrero, Mexico., Navarro-Tito N; Facultad de Ciencias Químico Biológicas, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N., 39090, Chilpancingo, Guerrero, Mexico. nnavarro@uagro.mx., Mendoza-Catalán MA; Facultad de Ciencias Químico Biológicas, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N., 39090, Chilpancingo, Guerrero, Mexico. mamendoza@uagro.mx.
Jazyk: angličtina
Zdroj: Medical oncology (Northwood, London, England) [Med Oncol] 2024 Jul 26; Vol. 41 (9), pp. 208. Date of Electronic Publication: 2024 Jul 26.
DOI: 10.1007/s12032-024-02454-x
Abstrakt: Currently, breast cancer is the most common cause of mortality caused by neoplasia in women worldwide. The unmet challenges of conventional cancer therapy are chemoresistance and lack of selectivity, which can lead to serious side effects in patients; therefore, new treatments based on natural compounds that serve as adjuvants in breast cancer therapy are urgently needed. Tocopherols are naturally occurring antioxidant compounds that have shown antitumor activity against several types of cancer, including breast cancer. This review summarizes the antitumoral activity of tocopherols, such as the antiproliferative, apoptotic, anti-invasive, and antioxidant effects of tocopherols, through different molecular mechanisms. According to the studies described, α-T, δ-T and γ-T are the most studied in breast tumor cells; however, α-T and γ-T show a more critical antitumor activity and significant potential as a complements to chemotherapeutic drugs against breast cancer, enhancing toxicity against tumor cells and preventing cytotoxicity in nontumor cells. However, the possible relationship between tocopherol intake, related to concentration, and the promotion of cancer in particular cases should not be ruled out, so additional studies are required to determine the correct dose to obtain the desired antitumor effect. Moreover, nanomicelles of D-α-tocopherol have promising potential as pharmaceutical excipients for drug delivery to improve the cytotoxicity and selectivity of first-line chemotherapeutics against breast cancer.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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