Ecological risks of high-ammonia environment with inhibited growth of Daphnia magna: Disturbed energy metabolism and oxidative stress.

Autor: Ma Y; School of Engineering, China Pharmaceutical University, Nanjing 210009, China., Liu Y; School of Engineering, China Pharmaceutical University, Nanjing 210009, China., Sun J; School of Engineering, China Pharmaceutical University, Nanjing 210009, China., Min P; School of Engineering, China Pharmaceutical University, Nanjing 210009, China., Liu W; State Key Laboratory for Environmental Protection of Water Ecological Health in the Middle and Lower Reaches of the Yangtze River, Jiangsu Provincial Academy of Environmental Science, Nanjing 210036, China., Li L; School of Engineering, China Pharmaceutical University, Nanjing 210009, China., Yi P; School of Engineering, China Pharmaceutical University, Nanjing 210009, China., Guo R; School of Engineering, China Pharmaceutical University, Nanjing 210009, China., Chen J; School of Engineering, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cjqalga@163.com.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 Oct 20; Vol. 948, pp. 174959. Date of Electronic Publication: 2024 Jul 24.
DOI: 10.1016/j.scitotenv.2024.174959
Abstrakt: High ammonia pollution is a common problem in water bodies. However, research on the mechanisms underlying the toxic effects on organisms at different nutritional levels is still insufficient. Herein, based on the environmental concentration, the toxic effects of high ammonia pollution on Daphnia magna were investigated. Overall, the feeding and filtration rates of D. magna were significantly decreased by ammonia. Growth inhibition of D. magna by ammonia was confirmed by the decreased body length. After ammonia exposure, the metabolic status of D. magna changed, the correlation network weakened, and the correlations between metabolites were disrupted. Changes occurred in metabolites primarily involved in oxidative stress, fatty acid oxidation, tricarboxylic acid cycle, and protein digestion, absorption, and synthesis, which were validated through alterations in multiple biomarkers. In addition, mitochondrial function was evaluated and was found to inhibit mitochondrial activity, which was accompanied by a decreased marker of mitochondrial activity contents and ATPase activity. Thus, the results suggested that energy metabolism and oxidative stress were involved in ammonia-induced growth toxicity. This study provides new insights into the impact of ammonia on aquatic ecological health.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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