Multi-functional adhesive hydrogel as bio-interface for wireless transient pacemaker.

Autor:	Zhang Q; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Zhao G; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Li Z; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Guo F; School of Public Health, The University of Hong Kong, Pok Fu Lam, HKSAR, China., Huang Y; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China; Hong Kong Center for Cerebra-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, 999077, Hong Kong, China., Guo G; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Wang J; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Zhou J; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China; Hong Kong Center for Cerebra-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, 999077, Hong Kong, China., Chow L; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Huang X; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., He X; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Gao Y; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Gao Z; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Yao K; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Qiu Y; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Zhao Z; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Zhang B; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China; Hong Kong Center for Cerebra-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, 999077, Hong Kong, China., Yang Y; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Liu Y; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Hu Y; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Wu M; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Li J; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China; Hong Kong Center for Cerebra-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, 999077, Hong Kong, China., Wu P; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Xu G; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., He P; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China., Yang Z; Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China. Electronic address: yzhih73@swmu.edu.cn., Yu X; Department of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong, China; Hong Kong Center for Cerebra-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, 999077, Hong Kong, China. Electronic address: xingeyu@cityu.edu.hk.
Jazyk:	angličtina
Zdroj:	Biosensors & bioelectronics [Biosens Bioelectron] 2024 Nov 01; Vol. 263, pp. 116597. Date of Electronic Publication: 2024 Jul 20.
DOI:	10.1016/j.bios.2024.116597
Abstrakt:	Traditional temporary cardiac pacemakers (TCPs), which employ transcutaneous leads and external wired power systems are battery-dependent and generally non-absorbable with rigidity, thereby necessitating surgical retrieval after therapy and resulting in potentially severe complications. Wireless and bioresorbable transient pacemakers have, hence, emerged recently, though hitting a bottleneck of unfavorable tissue-device bonding interface subject to mismatched mechanical modulus, low adhesive strength, inferior electrical performances, and infection risks. Here, to address such crux, we develop a multifunctional interface hydrogel (MIH) with superior electrical performance to facilitate efficient electrical exchange, comparable mechanical strength to natural heart tissue, robust adhesion property to enable stable device-tissue fixation (tensile strength: ∼30 kPa, shear strength of ∼30 kPa, and peel-off strength: ∼85 kPa), and good bactericidal effect to suppress bacterial growth. Through delicate integration of this versatile MIH with a leadless, battery-free, wireless, and transient pacemaker, the entire system exhibits stable and conformal adhesion to the beating heart while enabling precise and constant electrical stimulation to modulate the cardiac rhythm. It is envisioned that this versatile MIH and the proposed integration framework will have immense potential in overcoming key limitations of traditional TCPs, and may inspire the design of novel bioelectronic-tissue interfaces for next-generation implantable medical devices. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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