Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes.

Autor:	Irisarri I; Department of Applied Bioinformatics, University of Goettingen, Institute for Microbiology and Genetics, 37077 Göttingen, Germany.; Campus Institute Data Science (CIDAS), 37077 Göttingen, Germany.; Section Phylogenomics, Centre for Molecular Biodiversity Research, Leibniz Institute for the Analysis of Biodiversity Change (LIB), Museum of Nature, 20146 Hamburg, Germany., Lorente-Martínez H; Department of Biodiversity Ecology and Evolution, Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain., Strassert JFH; Evolutionary and Integrative Ecology, Leibniz Institute of Freshwater Ecology and Inland Fisheries, 12587 Berlin, Germany., Agorreta A; Department of Biodiversity Ecology and Evolution, Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain., Zardoya R; Department of Biodiversity and Evolutionary Biology, Museo Nacional de Ciencias Naturales (MNCN-CSIC), 28006 Madrid, Spain., San Mauro D; Department of Biodiversity Ecology and Evolution, Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain., de Vries J; Department of Applied Bioinformatics, University of Goettingen, Institute for Microbiology and Genetics, 37077 Göttingen, Germany.; Campus Institute Data Science (CIDAS), 37077 Göttingen, Germany.; Goettingen Center for Molecular Biosciences (GZMB), Department of Applied Bioinformatics, University of Goettingen, 37077 Göttingen, Germany.
Jazyk:	angličtina
Zdroj:	Genome biology and evolution [Genome Biol Evol] 2024 Aug 05; Vol. 16 (8).
DOI:	10.1093/gbe/evae164
Abstrakt:	Membrane intrinsic proteins (MIPs), including aquaporins (AQPs) and aquaglyceroporins (GLPs), form an ancient family of transporters for water and small solutes across biological membranes. The evolutionary history and functions of MIPs have been extensively studied in vertebrates and land plants, but their widespread presence across the eukaryotic tree of life suggests both a more complex evolutionary history and a broader set of functions than previously thought. That said, the early evolution of MIPs remains obscure. The presence of one GLP and four AQP clades across both bacteria and archaea suggests that the first eukaryotes could have possessed up to five MIPs. Here, we report on a previously unknown richness in MIP diversity across all major eukaryotic lineages, including unicellular eukaryotes, which make up the bulk of eukaryotic diversity. Three MIP clades have likely deep evolutionary origins, dating back to the last eukaryotic common ancestor (LECA), and support the presence of a complex MIP repertoire in early eukaryotes. Overall, our findings highlight the growing complexity of the reconstructed LECA genome: the dynamic evolutionary history of MIPs was set in motion when eukaryotes were in their infancy followed by radiative bursts across all main eukaryotic lineages. Competing Interests: Conflict of Interest The authors declare no competing interests. (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.)
Databáze:	MEDLINE
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