A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer.

Autor: Neamțu AA; Department of Toxicology, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.; Clinical County Emergency Hospital of Arad, Andrenyi Karoly Str., No. 2-4, 310037 Arad, Romania.; Clinical County Hospital of Târgu Mureș, 1 Decembrie 1918 Blvd., No. 1, 540011 Târgu Mures, Romania., Maghiar TA; Doctoral School of Biomedical Sciences, University of Oradea, Universității Str., No. 1, 410087 Oradea, Romania.; Clinical County Emergency Hospital of Oradea, Gheorghe Doja Str., No. 65, 410169 Oradea, Romania.; Pelican Hospital, Corneliu Coposu Str., No. 2, 410450 Oradea, Romania., Turcuș V; Faculty of Medicine and Faculty of Dentistry, 'Vasile Goldis' Western University of Arad, Liviu Rebreanu Str., No. 86, 310045 Arad, Romania.; National Institute for Economic Research 'Costin C. Kiritescu' of the Romanian Academy/Centre for Mountain Economy (CE-MONT), 725700 Suceava, Romania., Maghiar PB; Doctoral School of Biomedical Sciences, University of Oradea, Universității Str., No. 1, 410087 Oradea, Romania.; Clinical County Emergency Hospital of Oradea, Gheorghe Doja Str., No. 65, 410169 Oradea, Romania.; Pelican Hospital, Corneliu Coposu Str., No. 2, 410450 Oradea, Romania., Căpraru AM; Clinical County Hospital of Târgu Mureș, 1 Decembrie 1918 Blvd., No. 1, 540011 Târgu Mures, Romania.; Poiana Mare Psychiatry Hospital, Gării Str., No. 40, 207470 Poiana Mare, Romania., Lazar BA; Clinical County Hospital of Târgu Mureș, 1 Decembrie 1918 Blvd., No. 1, 540011 Târgu Mures, Romania., Dehelean CA; Department of Toxicology, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania., Pop OL; Faculty of Medicine and Pharmacy, University of Oradea, Universității Str., No. 1, 410081 Oradea, Romania., Neamțu C; Clinical County Emergency Hospital of Arad, Andrenyi Karoly Str., No. 2-4, 310037 Arad, Romania.; Faculty of Medicine and Faculty of Dentistry, 'Vasile Goldis' Western University of Arad, Liviu Rebreanu Str., No. 86, 310045 Arad, Romania., Totolici BD; Clinical County Emergency Hospital of Arad, Andrenyi Karoly Str., No. 2-4, 310037 Arad, Romania.; Faculty of Medicine and Faculty of Dentistry, 'Vasile Goldis' Western University of Arad, Liviu Rebreanu Str., No. 86, 310045 Arad, Romania., Mathe E; Faculty of Medicine and Faculty of Dentistry, 'Vasile Goldis' Western University of Arad, Liviu Rebreanu Str., No. 86, 310045 Arad, Romania.; Institute of Nutrition, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Böszörményi Str., No. 138, H-4032 Debrecen, Hungary.
Jazyk: angličtina
Zdroj: Current issues in molecular biology [Curr Issues Mol Biol] 2024 Jul 02; Vol. 46 (7), pp. 6783-6804. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.3390/cimb46070405
Abstrakt: Chlorogenic acids are plant secondary metabolites, chemically-polyphenols with similar biological activity, formed through the esterification of quinic acid and hydrocinnamic acid moieties. They are best known for their high concentration in coffee and other dietary sources and the antioxidant properties that they exhibit. Both chlorogenic acids and plant extracts containing significant amounts of the compounds show promising in vitro activity against colorectal cancer. With coffee being the most popular drink in the world, and colorectal cancer at an unfortunate peak in incidence and mortality, the mechanisms through which the anti-tumorigenic effect of chlorogenic acids could be functionalized for CRC prevention seem appealing to study. Therefore, this review aims to enable a better understanding of the modes of action of chlorogenic acids in combating carcinogenesis, with a focus on cell cycle arrest, the induction of apoptosis, and the modulation of Wnt, Pi3K/Akt, and MAPK signal transduction pathways, alongside the reduction in the number of inflammatory cytokines and chemokines and the counterintuitive beneficial elevation of oxidative stress.
Databáze: MEDLINE