Altered Monocyte and Lymphocyte Phenotypes Associated with Pathogenesis and Clinical Efficacy of Progestogen Therapy for Peritoneal Endometriosis in Adolescents.

Autor: Khashchenko EP; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia., Krechetova LV; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia., Vishnyakova PA; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.; Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117997 Moscow, Russia., Fatkhudinov TK; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.; Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117997 Moscow, Russia.; Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Inviyaeva EV; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia., Vtorushina VV; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia., Gantsova EA; Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117997 Moscow, Russia.; Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Kiseleva VV; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.; Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117997 Moscow, Russia., Poltavets AS; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia., Elchaninov AV; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.; Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 117997 Moscow, Russia.; Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia.; Department of Histology, Embryology and Cytology, Pirogov Russian National Research Medical University (Pirogov Medical University), 117997 Moscow, Russia., Uvarova EV; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.; Department of Obstetrics and Gynecology, Sechenov First Moscow State Medical University, Trubetskaya str. 8, bld. 2, 119991 Moscow, Russia., Chuprynin VD; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia., Sukhikh GT; FSBI 'National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov' Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.; Department of Obstetrics and Gynecology, Sechenov First Moscow State Medical University, Trubetskaya str. 8, bld. 2, 119991 Moscow, Russia.
Jazyk: angličtina
Zdroj: Cells [Cells] 2024 Jul 12; Vol. 13 (14). Date of Electronic Publication: 2024 Jul 12.
DOI: 10.3390/cells13141187
Abstrakt: Background : Immunological imbalances characteristic of endometriosis may develop as early as the primary manifestations of the disease in adolescence. Objective : To evaluate subpopulation dynamics of monocytes and lymphocytes in peripheral blood and peritoneal fluid of adolescents with peritoneal endometriosis at diagnosis and after 1-year progestogen therapy. Methods : This study included 70 girls, 13-17 years old, diagnosed laparoscopically with peritoneal endometriosis ( n = 50, main group) or paramesonephric cysts ( n = 20, comparison group). Phenotypes of monocytes and lymphocytes of the blood and macrophages of the peritoneal fluid were analyzed by flow cytometry at diagnosis and during progestogen therapy. Results : Differential blood counts of CD16 + ( p < 0.001) and CD86 + ( p = 0.017) monocytes were identified as independent risk factors for peritoneal endometriosis in adolescents. During the treatment, cytotoxic lymphocytes CD56dimCD16bright ( p = 0.049) and CD206+ monocytes ( p < 0.001) significantly increased while CD163+ monocytes decreased in number ( p = 0.017). The CD56dimCD16bright blood counts before ( p < 0.001) and during progestogen therapy ( p = 0.006), as well as CD206 + blood counts during the treatment ( p = 0.038), were associated with the efficacy of pain relief after 1-year progestogen therapy. Conclusions : Adolescents with peritoneal endometriosis have altered counts of pro- and anti-inflammatory monocytes and lymphocytes both before and after 1-year progestogen therapy, correlating with treatment efficacy and justifying long-term hormonal therapy.
Databáze: MEDLINE
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