Differences in corneal nerve fiber density and fiber length in patients with painful chronic idiopathic axonal polyneuropathy and diabetic polyneuropathy.

Autor: Nieuwenhoff MD; Department of Anesthesiology and Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Centre for Human Drug Research, Leiden, The Netherlands., Nguyen HT; Department of Ophthalmology, Amsterdam UMC location VU University Medical Center, Amsterdam, The Netherlands., Niehof SP; Department of Anesthesiology and Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Huygen FJPM; Department of Anesthesiology and Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Verma A; Biogen, Cambridge, Massachusetts, USA., Klaassen ES; Centre for Human Drug Research, Leiden, The Netherlands., Bechakra M; Department of Anesthesiology and Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Geelhoed WJ; Centre for Human Drug Research, Leiden, The Netherlands., Jongen JLM; Department of Anesthesiology and Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Moll AC; Department of Ophthalmology, Amsterdam UMC location VU University Medical Center, Amsterdam, The Netherlands., Vrancken AFJE; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands., Petzold A; Department of Ophthalmology, Amsterdam UMC location VU University Medical Center, Amsterdam, The Netherlands.; Department of Neurology, Amsterdam UMC location VU University Medical Center, Amsterdam, The Netherlands.; Moorfields Eye Hospital, The National Hospital for Neurology and Neurosurgery and the Queen Square Institute of Neurology, UCL, London, UK., Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk: angličtina
Zdroj: Muscle & nerve [Muscle Nerve] 2024 Oct; Vol. 70 (4), pp. 782-790. Date of Electronic Publication: 2024 Jul 26.
DOI: 10.1002/mus.28213
Abstrakt: Introduction/aims: Corneal confocal microscopy (CCM) detects small nerve fiber loss and correlates with skin biopsy findings in diabetic neuropathy. In chronic idiopathic axonal polyneuropathy (CIAP) this correlation is unknown. Therefore, we compared CCM and skin biopsy in patients with CIAP to healthy controls, patients with painful diabetic neuropathy (PDN) and diabetics without overt neuropathy (DM).
Methods: Participants with CIAP and suspected small fiber neuropathy (n = 15), PDN (n = 16), DM (n = 15), and healthy controls (n = 16) underwent skin biopsy and CCM testing. Inter-center intraclass correlation coefficients (ICC) were calculated for CCM parameters.
Results: Compared with healthy controls, patients with CIAP and PDN had significantly fewer nerve fibers in the skin (IENFD: 5.7 ± 2.3, 3.0 ± 1.8, 3.9 ± 1.5 fibers/mm, all p < .05). Corneal nerve parameters in CIAP (fiber density 23.8 ± 4.9 no./mm 2 , branch density 16.0 ± 8.8 no./mm 2 , fiber length 13.1 ± 2.6 mm/mm 2 ) were not different from healthy controls (24.0 ± 6.8 no./mm 2 , 22.1 ± 9.7 no./mm 2 , 13.5 ± 3.5 mm/mm 2 , all p > .05). In patients with PDN, corneal nerve fiber density (17.8 ± 5.7 no./mm 2 ) and fiber length (10.5 ± 2.7 mm/mm 2 ) were reduced compared with healthy controls (p < .05). CCM results did not correlate with IENFD in CIAP patients. Inter-center ICC was 0.77 for fiber density and 0.87 for fiber length.
Discussion: In contrast to patients with PDN, corneal nerve parameters were not decreased in patients with CIAP and small nerve fiber damage. Therefore, CCM is not a good biomarker for small nerve fiber loss in CIAP patients.
(© 2024 The Author(s). Muscle & Nerve published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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