Clinical characteristics, anti-SARS-CoV-2 IgG titers, and inflammatory markers in individuals with post-COVID-19 condition in Kenya: a cross-sectional study.

Autor:	Theuri M; Department of Medical Laboratory Science, Kenyatta University, Nairobi, Kenya., Ndombi EM; Department of Medical Microbiology and Parasitology, Kenyatta University, Nairobi, Kenya., Thamaini P; Department of Human Pathology, Kenyatta University, Nairobi, Kenya., Ogutu JO; Department of Medical Microbiology and Parasitology, Kenyatta University, Nairobi, Kenya., Onsongo L; Department of Community and Reproductive Health Nursing, Kenyatta University, Nairobi, Kenya., Madete JK; Department of Electrical and Electronic Engineering, Kenyatta University, Nairobi, Kenya., Ofula V; Centre for Virus Research, kenya Medical Research Institute, Nairobi, Kenya., Gitau S; Department of Pharmacology and Clinical Pharmacy, Kenyatta University, Nairobi, Kenya., Mwangi G; Department of Pharmacology and Clinical Pharmacy, Kenyatta University, Nairobi, Kenya., Okemo P; Department of Biochemistry, Microbiology, and Biotechnology, Kenyatta University, Nairobi, Kenya.
Jazyk:	angličtina
Zdroj:	PeerJ [PeerJ] 2024 Jul 22; Vol. 12, pp. e17723. Date of Electronic Publication: 2024 Jul 22 (Print Publication: 2024).
DOI:	10.7717/peerj.17723
Abstrakt:	Background: Post-coronavirus disease 2019 (post-COVID-19) is associated with considerable morbidity and reduced quality of life. However, studies characterizing the post-COVID-19 condition in Kenya are limited. This study aimed to determine the prevalence of post-COVID-19 condition and determine the clinical characteristics, anti-SARS-CoV-2 IgG titers, and concentrations of inflammatory markers of individuals with post-COVID-19 condition in Kenya. Methods: This descriptive cross-sectional study was conducted at the Kenyatta University Health Unit, Kenya. Demographic and clinical data were collected using a questionnaire. The serum levels of anti-SARS-CoV-2 antibodies, interleukin 6 (IL-6), and C-reactive protein (CRP) were quantified by enzyme-linked immunosorbent assays. Independent samples t-test was used to compare the anti-SARS-CoV-2 IgG, IL-6, and CRP levels between the participants with and without post-COVID-19 symptoms. The case definition for post-COVID-19 condition was persistence of acute COVID-19 symptoms or emergence of new symptoms 3 months after COVID-19 diagnosis, symptoms lasting for ≥2 months, and absence of any other etiological basis to explain the symptoms. Results: A total of 189 volunteers were recruited in this study (median age: 21 years, range: 18-71 years; male, 49.2%). Forty participants reported having had at least one COVID-19 positive diagnosis in the past, of which 12 (30%) complained of post-COVID-19 symptoms. Significant differences in the number and duration of symptoms were observed between the individuals with and without post-COVID-19 symptoms ( t -statistic = 2.87, p = 0.01; t -statistic = 2.39, p = 0.02, respectively). However, no significant differences in serum levels of anti-SARS-CoV-2 IgG, IL-6, and CRP were observed between the two groups ( P = 0.08, 0.9, and 0.28, respectively). Conclusion: These findings suggest that post-COVID-19 condition is a health concern even for a relatively young population in Kenya and globally. This condition requires more attention and well-designed studies to better define it and identify clinical chemistry markers that can be used for its diagnosis. Competing Interests: The authors declare that they have no competing interests. (© 2024 Theuri et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu