Machine learning to promote translational research: predicting patent and clinical trial inclusion in dementia research.

Autor:	Beinat M; Institute of Psychiatry Psychology and Neuroscience, King's College London, SE5 8AB, London, UK., Beinat J; Independent Researcher, 1071XA, Amsterdam, The Netherlands., Shoaib M; School of Life and Medical Sciences, University of Hertfordshire, AL10 9AB, Hatfield, UK., Magenti JG; Magenti Methodologies, CB4 3JG, Cambridge, UK.
Jazyk:	angličtina
Zdroj:	Brain communications [Brain Commun] 2024 Jul 25; Vol. 6 (4), pp. fcae230. Date of Electronic Publication: 2024 Jul 25 (Print Publication: 2024).
DOI:	10.1093/braincomms/fcae230
Abstrakt:	Projected to impact 1.6 million people in the UK by 2040 and costing £25 billion annually, dementia presents a growing challenge to society. This study, a pioneering effort to predict the translational potential of dementia research using machine learning, hopes to address the slow translation of fundamental discoveries into practical applications despite dementia's significant societal and economic impact. We used the Dimensions database to extract data from 43 091 UK dementia research publications between the years 1990 and 2023, specifically metadata (authors, publication year, etc.), concepts mentioned in the paper and the paper abstract. To prepare the data for machine learning, we applied methods such as one-hot encoding and word embeddings. We trained a CatBoost Classifier to predict whether a publication will be cited in a future patent or clinical trial. We trained several model variations. The model combining metadata, concept and abstract embeddings yielded the highest performance: for patent predictions, an area under the receiver operating characteristic curve of 0.84 and 77.17% accuracy; for clinical trial predictions, an area under the receiver operating characteristic curve of 0.81 and 75.11% accuracy. The results demonstrate that integrating machine learning within current research methodologies can uncover overlooked publications, expediting the identification of promising research and potentially transforming dementia research by predicting real-world impact and guiding translational strategies. Competing Interests: The authors report no competing interests. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze:	MEDLINE
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