The potential of miRNA-based approaches in glioblastoma: An update in current advances and future perspectives.

Autor:	Ordóñez-Rubiano EG; School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.; Department of Neurosurgery, Fundación Universitaria de Ciencias de La Salud, Hospital de San José - Sociedad de Cirugía de Bogotá, Bogotá D.C., Colombia.; Department of Neurosurgery, Fundación Santa Fe de Bogotá, Bogotá, Colombia., Rincón-Arias N; Department of Neurosurgery, Fundación Universitaria de Ciencias de La Salud, Hospital de San José - Sociedad de Cirugía de Bogotá, Bogotá D.C., Colombia., Espinosa S; Department of Neurosurgery, Fundación Universitaria de Ciencias de La Salud, Hospital de San José - Sociedad de Cirugía de Bogotá, Bogotá D.C., Colombia., Shelton WJ; School of Medicine, Universidad de Los Andes, Bogotá, Colombia., Salazar AF; School of Medicine, Universidad de Los Andes, Bogotá, Colombia., Cómbita A; School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.; Department of Microbiology, Universidad Nacional de Colombia, Bogotá, Colombia., Baldoncini M; School of Medicine, Laboratory of Microsurgical Neuroanatomy, Second Chair of Gross Anatomy, University of Buenos Aires, Buenos Aires, Argentina.; Department of Neurological Surgery, Hospital San Fernando, Buenos Aires, Argentina., Luzzi S; Neurosurgery Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Payán-Gómez C; Dirección Académica, Universidad Nacional de Colombia, Sede de La Paz, La Paz, Colombia., Gómez-Amarillo DF; Department of Neurosurgery, Fundación Santa Fe de Bogotá, Bogotá, Colombia., Hakim F; Department of Neurosurgery, Fundación Santa Fe de Bogotá, Bogotá, Colombia., Patiño-Gómez JG; Department of Neurosurgery, Fundación Universitaria de Ciencias de La Salud, Hospital de San José - Sociedad de Cirugía de Bogotá, Bogotá D.C., Colombia., Parra-Medina R; Department of Pathology, Instituto Nacional de Cancerología, Bogotá, Colombia.; Research Institute, Fundación Universitaria de Ciencias de La Salud (FUCS), Hospital de San José - Sociedad de Cirugía de Bogotá, Bogotá, Colombia.
Jazyk:	angličtina
Zdroj:	Current research in pharmacology and drug discovery [Curr Res Pharmacol Drug Discov] 2024 Jun 29; Vol. 7, pp. 100193. Date of Electronic Publication: 2024 Jun 29 (Print Publication: 2024).
DOI:	10.1016/j.crphar.2024.100193
Abstrakt:	Glioblastoma (GBM) is the most common malignant central nervous system tumor. The emerging field of epigenetics stands out as particularly promising. Notably, the discovery of micro RNAs (miRNAs) has paved the way for advancements in diagnosing, treating, and prognosticating patients with brain tumors. We aim to provide an overview of the emergence of miRNAs in GBM and their potential role in the multifaceted management of this disease. We discuss the current state of the art regarding miRNAs and GBM. We performed a narrative review using the MEDLINE/PUBMED database to retrieve peer-reviewed articles related to the use of miRNA approaches for the treatment of GBMs. MiRNAs are intrinsic non-coding RNA molecules that regulate gene expression mainly through post-transcriptional mechanisms. The deregulation of some of these molecules is related to the pathogenesis of GBM. The inclusion of molecular characterization for the diagnosis of brain tumors and the advent of less-invasive diagnostic methods such as liquid biopsies, highlights the potential of these molecules as biomarkers for guiding the management of brain tumors such as GBM. Importantly, there is a need for more studies to better examine the application of these novel molecules. The constantly changing characterization and approach to the diagnosis and management of brain tumors broaden the possibilities for the molecular inclusion of novel epigenetic molecules, such as miRNAs, for a better understanding of this disease. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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