Helicobacter pylori-Negative Differentiated Intramucosal Gastric Cancer in the Antrum With a Morphological Change in Four Years: A Case Series.

Autor:	Obana T; Department of Gastroenterology, Kyojinkai Komatsu Hospital, Osaka, JPN., Yamasaki S; Department of Gastroenterology, Kyojinkai Komatsu Hospital, Osaka, JPN., Yakami Y; Department of Gastroenterology, Kyojinkai Komatsu Hospital, Osaka, JPN.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 25; Vol. 16 (6), pp. e63148. Date of Electronic Publication: 2024 Jun 25 (Print Publication: 2024).
DOI:	10.7759/cureus.63148
Abstrakt:	This case report presents two cases of differentiated intramucosal gastric cancer in the antrum. Both patients reported no history of Helicobacter pylori eradication therapy, and endoscopy and diagnostic tests indicated no H. pylori infection. Case 1 is a female patient in her 70s. Esophagoduodenogastroscopy (EGD) detected a depressed lesion. Adenocarcinoma was suspected; thus, endoscopic submucosal dissection (ESD) was performed to resect the lesion. The histological result was well-differentiated tubular adenocarcinoma, which predominantly demonstrated an intestinal mucin phenotype. The existence of a small elevated lesion in the same location was confirmed by reviewing the previous endoscopic record 52 months earlier. Case 2 is a male patient in his 60s in whom screening EGD detected an elevated lesion. The biopsy indicated gastric adenoma, and ESD was performed. The histological diagnosis was well-to-moderately differentiated tubular adenocarcinoma with a pure gastric phenotype. These results indicate that H. pylori -negative differentiated gastric carcinomas in the antrum occur as small elevated lesions that may gradually progress to a depressed form during a relatively long clinical course. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Obana et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu