Metal-based nanoparticle in cancer treatment: lessons learned and challenges.

Autor:	Hheidari A; Department of Mechanical Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran., Mohammadi J; School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran., Ghodousi M; Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, United States., Mahmoodi M; Bio-microfluidics Lab, Department of Electrical Engineering and Information Technology, Iranian Research Organization for Science and Technology, Tehran, Iran., Ebrahimi S; School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran., Pishbin E; Bio-microfluidics Lab, Department of Electrical Engineering and Information Technology, Iranian Research Organization for Science and Technology, Tehran, Iran., Rahdar A; Department of Physics, University of Zabol, Zabol, Iran.
Jazyk:	angličtina
Zdroj:	Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2024 Jul 11; Vol. 12, pp. 1436297. Date of Electronic Publication: 2024 Jul 11 (Print Publication: 2024).
DOI:	10.3389/fbioe.2024.1436297
Abstrakt:	Cancer, being one of the deadliest diseases, poses significant challenges despite the existence of traditional treatment approaches. This has led to a growing demand for innovative pharmaceutical agents that specifically target cancer cells for effective treatment. In recent years, the use of metal nanoparticles (NPs) as a promising alternative to conventional therapies has gained prominence in cancer research. Metal NPs exhibit unique properties that hold tremendous potential for various applications in cancer treatment. Studies have demonstrated that certain metals possess inherent or acquired anticancer capabilities through their surfaces. These properties make metal NPs an attractive focus for therapeutic development. In this review, we will investigate the applicability of several distinct classes of metal NPs for tumor targeting in cancer treatment. These classes may include gold, silver, iron oxide, and other metals with unique properties that can be exploited for therapeutic purposes. Additionally, we will provide a comprehensive summary of the risk factors associated with the therapeutic application of metal NPs. Understanding and addressing these factors will be crucial for successful clinical translation and to mitigate any potential challenges or failures in the translation of metal NP-based therapies. By exploring the therapeutic potential of metal NPs and identifying the associated risk factors, this review aims to contribute to the advancement of cancer treatment strategies. The anticipated outcome of this review is to provide valuable insights and pave the way for the advancement of effective and targeted therapies utilizing metal NPs specifically for cancer patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Hheidari, Mohammadi, Ghodousi, Mahmoodi, Ebrahimi, Pishbin and Rahdar.)
Databáze:	MEDLINE
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