Exploring the Chemical Space of the Exposome: How Far Have We Gone?

Autor:	Samanipour S; Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Amsterdam 1090 GD, The Netherlands.; UvA Data Science Center, University of Amsterdam, Amsterdam 1090 GD, The Netherlands.; Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Cornwall Street, Woolloongabba, Queensland 4102, Australia., Barron LP; MRC Centre for Environment and Health, Environmental Research Group, School of Public Health, Faculty of Medicine, Imperial College London, London W12 0BZ, United Kingdom.; Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Amsterdam 1090 GD, The Netherlands., van Herwerden D; Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Amsterdam 1090 GD, The Netherlands., Praetorius A; Institute for Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam, Amsterdam 1090 GD, The Netherlands., Thomas KV; Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Cornwall Street, Woolloongabba, Queensland 4102, Australia., O'Brien JW; Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Cornwall Street, Woolloongabba, Queensland 4102, Australia.; Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Amsterdam 1090 GD, The Netherlands.
Jazyk:	angličtina
Zdroj:	JACS Au [JACS Au] 2024 Jun 20; Vol. 4 (7), pp. 2412-2425. Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024).
DOI:	10.1021/jacsau.4c00220
Abstrakt:	Around two-thirds of chronic human disease can not be explained by genetics alone. The Lancet Commission on Pollution and Health estimates that 16% of global premature deaths are linked to pollution. Additionally, it is now thought that humankind has surpassed the safe planetary operating space for introducing human-made chemicals into the Earth System. Direct and indirect exposure to a myriad of chemicals, known and unknown, poses a significant threat to biodiversity and human health, from vaccine efficacy to the rise of antimicrobial resistance as well as autoimmune diseases and mental health disorders. The exposome chemical space remains largely uncharted due to the sheer number of possible chemical structures, estimated at over 10 60 unique forms. Conventional methods have cataloged only a fraction of the exposome, overlooking transformation products and often yielding uncertain results. In this Perspective, we have reviewed the latest efforts in mapping the exposome chemical space and its subspaces. We also provide our view on how the integration of data-driven approaches might be able to bridge the identified gaps. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu