Pd-catalyzed Suzuki-type cross-coupling of 2-pyridyl carbamoyl fluorides.

Autor:	Jabbarpoor M; Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada. cmle@yorku.ca., LeBlanc J; Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada. cmle@yorku.ca., Chen Z; Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada. cmle@yorku.ca., Cadwallader D; Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada. cmle@yorku.ca., Le CM; Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada. cmle@yorku.ca.
Jazyk:	angličtina
Zdroj:	Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Aug 13; Vol. 60 (66), pp. 8700-8703. Date of Electronic Publication: 2024 Aug 13.
DOI:	10.1039/d4cc02431a
Abstrakt:	We describe a palladium-catalyzed Suzuki-type cross-coupling reaction of 2-pyridyl carbamoyl fluorides with boronic acids, which provides entry to medicinally relevant pyridyl amides. Mechanistic studies, including the synthesis and reactivity of carbamoyl Pd-F complexes, reveal the importance of both the fluoride electrophile and nitrogen directing group for aiding reactivity.
Databáze:	MEDLINE
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