Whole-Brain Vascular Architecture Mapping Identifies Region-Specific Microvascular Profiles In Vivo.
| Autor: | Hohmann A; From the Department of Neurology (A.H., W.W.), Heidelberg University Hospital, Heidelberg, Germany., Zhang K; Department of Diagnostic and Interventional Radiology (K.Z.), Heidelberg University Hospital, Heidelberg, Germany., Mooshage CM; Department of Neuroradiology (C.M.M., J.M.E.J., M.B., F.T.K.), Heidelberg University Hospital, Heidelberg, Germany., Jende JME; Department of Neuroradiology (C.M.M., J.M.E.J., M.B., F.T.K.), Heidelberg University Hospital, Heidelberg, Germany., Rotkopf LT; Division of Radiology (L.T.R., H.-P.S., F.T.K.) German Cancer Research Center, Heidelberg, Germany., Schlemmer HP; Division of Radiology (L.T.R., H.-P.S., F.T.K.) German Cancer Research Center, Heidelberg, Germany., Bendszus M; Department of Neuroradiology (C.M.M., J.M.E.J., M.B., F.T.K.), Heidelberg University Hospital, Heidelberg, Germany., Wick W; From the Department of Neurology (A.H., W.W.), Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology (W.W.), German Cancer Research Center, Heidelberg, Germany., Kurz FT; Department of Neuroradiology (C.M.M., J.M.E.J., M.B., F.T.K.), Heidelberg University Hospital, Heidelberg, Germany felixtobias.kurz@hug.ch.; Division of Radiology (L.T.R., H.-P.S., F.T.K.) German Cancer Research Center, Heidelberg, Germany.; Division of Neuroradiology (F.T.K.), University Hospital Geneva, Geneva, Switzerland. |
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| Jazyk: | angličtina |
| Zdroj: | AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2024 Sep 09; Vol. 45 (9), pp. 1346-1354. Date of Electronic Publication: 2024 Sep 09. |
| DOI: | 10.3174/ajnr.A8344 |
| Abstrakt: | Background and Purpose: The novel MR imaging technique of vascular architecture mapping allows in vivo characterization of local changes in cerebral microvasculature, but reference ranges for vascular architecture mapping parameters in healthy brain tissue are lacking, limiting its potential applicability as an MR imaging biomarker in clinical practice. We conducted whole-brain vascular architecture mapping in a large cohort to establish vascular architecture mapping parameter references ranges and identify region-specific cortical and subcortical microvascular profiles. Materials and Methods: This was a single-center examination of adult patients with unifocal, stable low-grade gliomas with multiband spin- and gradient-echo EPI sequence at 3T using parallel imaging. Voxelwise plotting of resulting values for gradient-echo (R Results: Prevalence of vascular risk factors among subjects ( n = 106; mean age, 39.2 [SD, 12.5] years; 56 women) was similar to those in the German population. Compared with WM, we found cortical GM to have larger mean vascular calibers (5.80 [SD, 0.59] versus 4.25 [SD, 0.62] P < .001), increased blood volume fraction (20.40 [SD, 4.49] s -1 versus 11.05 [SD, 2.44] s -1 ; P < .001), and a dominance of venous vessels. Distinct microvascular profiles emerged for cortical GM, where vascular architecture mapping vessel type indicator differed, eg, between the thalamus and cortical GM (mean, -2.47 [SD, 4.02] s -2 versus -5.41 [SD, 2.84] s -2 ; P < .001). Intraclass correlation coefficient values indicated overall high test-retest reliability for vascular architecture mapping parameter mean values when comparing multiple scans per subject. Conclusions: Whole-brain vascular architecture mapping in the adult brain reveals region-specific microvascular profiles. The obtained parameter reference ranges for distinct anatomic and functional brain areas may be used for future vascular architecture mapping studies on cerebrovascular pathologies and might facilitate early discovery of microvascular changes, in, eg, neurodegeneration and neuro-oncology. (© 2024 by American Journal of Neuroradiology.) |
| Databáze: | MEDLINE |
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