Targeting white adipose tissue to combat insulin resistance.

Autor: Huang Y; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada., Gao P; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada., Young LH; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: lawrence.young@yale.edu., Qi D; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. Electronic address: dake.qi@umanitoba.ca.
Jazyk: angličtina
Zdroj: Trends in pharmacological sciences [Trends Pharmacol Sci] 2024 Oct; Vol. 45 (10), pp. 868-871. Date of Electronic Publication: 2024 Jul 24.
DOI: 10.1016/j.tips.2024.06.008
Abstrakt: Metabolic and endocrine dysfunction of white adipose tissue (WAT) is linked to inflammation, which has been considered a key mechanism of insulin resistance (IR). However, recent studies revealed non-inflammatory mechanisms of IR in WAT, which may trigger inflammation and could be developed as a novel strategy to counteract IR.
Competing Interests: Declaration of interest The authors report no conflicts of interest, financial or otherwise, in this work.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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