Protective role of cells and spores of Shouchella clausii SF174 against fructose-induced gut dysfunctions in small and large intestine.

Autor: Saggese A; Department of Biology, University of Naples Federico II, Naples, Italy., Barrella V; Department of Biology, University of Naples Federico II, Naples, Italy; NBFC, National Biodiversity Future Center, Palermo, Italy., Porzio AD; Department of Biology, University of Naples Federico II, Naples, Italy., Troise AD; National Research Council, Proteomics, Metabolomics & Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment, Portici Naples, Italy., Scaloni A; National Research Council, Proteomics, Metabolomics & Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment, Portici Naples, Italy., Cigliano L; Department of Biology, University of Naples Federico II, Naples, Italy; Task Force on Microbiome Studies, University of Naples Federico II, Napoli, Italy., Scala G; Department of Biology, University of Naples Federico II, Naples, Italy., Baccigalupi L; NBFC, National Biodiversity Future Center, Palermo, Italy; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy; Task Force on Microbiome Studies, University of Naples Federico II, Napoli, Italy., Iossa S; Department of Biology, University of Naples Federico II, Naples, Italy; NBFC, National Biodiversity Future Center, Palermo, Italy; Task Force on Microbiome Studies, University of Naples Federico II, Napoli, Italy., Ricca E; Department of Biology, University of Naples Federico II, Naples, Italy; Task Force on Microbiome Studies, University of Naples Federico II, Napoli, Italy. Electronic address: ezio.ricca@unina.it., Mazzoli A; Department of Biology, University of Naples Federico II, Naples, Italy.
Jazyk: angličtina
Zdroj: The Journal of nutritional biochemistry [J Nutr Biochem] 2024 Nov; Vol. 133, pp. 109706. Date of Electronic Publication: 2024 Jul 23.
DOI: 10.1016/j.jnutbio.2024.109706
Abstrakt: The oral administration of probiotics is nowadays recognized as a strategy to treat or prevent the consequences of unhealthy dietary habits. Here we analyze and compare the effects of the oral administration of vegetative cells or spores of Shouchella clausii SF174 in counteracting gut dysfunctions induced by 6 weeks of high fructose intake in a rat model. Gut microbiota composition, tight junction proteins, markers of inflammation and redox homeostasis were evaluated in ileum and colon in rats fed fructose rich diet and supplemented with cells or spores of Shouchella clausii SF174. Our results show that both spores and cells of SF174 were effective in preventing the fructose-induced metabolic damage to the gut, namely establishment of "leaky gut", inflammation and oxidative damage, thus preserving gut function. Our results also suggest that vegetative cells and germination-derived cells metabolize part of the ingested fructose at the ileum level.
Competing Interests: Declarations of competing interests ER acts as a consultant for Gruppo Savio (Italy) that has the rights for the commercialization of strain SF174. Gruppo Savio (Italy) had no role in the design of the study, in the collection, analyses or interpretation of data or in the writing of the manuscript.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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