The contribution of environmental pollutants to the risk of autism and other neurodevelopmental disorders: A systematic review of case-control studies.

Autor: Tartaglione AM; Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy. Electronic address: annamaria.tartaglione@iss.it., Camoni L; Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy., Calamandrei G; Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy., Chiarotti F; Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy., Venerosi A; Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2024 Sep; Vol. 164, pp. 105815. Date of Electronic Publication: 2024 Jul 23.
DOI: 10.1016/j.neubiorev.2024.105815
Abstrakt: Exposure to environmental pollutants, such as metals, pesticides, and air pollutants during early life, is a risk factor for neurodevelopmental disorders (NDDs), including Autism Spectrum Disorder (ASD). Our systematic review aimed to select and summarize more recent case-control studies that examined the association between prenatal and early postnatal exposure to environmental pollutants and NDDs. We searched five databases (Web of Science, PubMed, Embase, Scopus, Ovid), screened 2261 records, and included 24 eligible case-control studies. Meta-analyses were conducted on subgroups of at least three studies that shared both the outcome and the exposure. A noteworthy discovery from this literature review is the existence of non-linear or non-monotonic dose-response relationships between the exposure to certain metals and the risk of ASD. The meta-analysis revealed a significant association between exposure to particular matter (PM) 10 during the first year of life and the risk of ASD. Overall, studies included in our systematic review indicate that exposure to several pollutants within the first three years of life was significantly associated with the risk of NDDs.
Competing Interests: Declaration of Competing Interest None
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: