Intratympanic Lidocaine as a Potent Remedy for Tinnitus in Sudden Sensorineural Hearing Loss: A Double-Blind, Randomized Clinical Trial.
| Autor: | Zhang D; Department of Otorhinolaryngology, Head and Neck Surgery, Meishan Municipal People's Hospital, Meishan, Sichuan, China., Li D, Chen T, Feng X, Zhang J |
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| Jazyk: | angličtina |
| Zdroj: | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology [Otol Neurotol] 2024 Sep 01; Vol. 45 (8), pp. 849-854. Date of Electronic Publication: 2024 Jul 25. |
| DOI: | 10.1097/MAO.0000000000004283 |
| Abstrakt: | Objective: This study evaluates intratympanic lidocaine's efficacy and safety for tinnitus relief in sudden sensorineural hearing loss (SSNHL) patients. Methods: In a double-blind randomized controlled trial, 100 SSNHL patients with unilateral tinnitus received either intratympanic lidocaine or saline plus usual care. Treatment impact was assessed at 1 and 3 months using the Tinnitus Handicap Inventory, subjective visual analog scale, pure-tone audiometry. Results: The lidocaine group demonstrated significant tinnitus relief according to the Tinnitus Handicap Inventory and visual analog scale, without pure-tone audiometry improvement or serious adverse events throughout the study period. Conclusion: Intratympanic lidocaine provides a safe, efficacious treatment option for SSNHL tinnitus. Further studies should refine the dosage and delivery parameters because of SSNHL's heterogenous nature. Competing Interests: The authors disclose no conflicts of interest. (Copyright © 2024, Otology & Neurotology, Inc.) |
| Databáze: | MEDLINE |
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