Aversive memories can be weakened during human sleep via the reactivation of positive interfering memories.

Autor:	Xia T; Department of Psychology, The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong Special Administrative Region 999077, China., Chen D; Department of Psychology, The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong Special Administrative Region 999077, China., Zeng S; Department of Psychology, The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong Special Administrative Region 999077, China.; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215.; Department of Psychiatry, Harvard Medical School, Boston, MA 02215., Yao Z; Department of Psychology, The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong Special Administrative Region 999077, China., Liu J; Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region 999077, China., Qin S; State Key Laboratory of Cognitive Neuroscience and Learning and International Data Group McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China., Paller KA; Cognitive Neuroscience Program and Department of Psychology, Northwestern University, Evanston, IL 60208., Torres Platas SG; Cognitive Neuroscience Program and Department of Psychology, Northwestern University, Evanston, IL 60208., Antony JW; Department of Psychology & Child Development, California Polytechnic State University, San Luis Obispo, CA 93407., Hu X; Department of Psychology, The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong Special Administrative Region 999077, China.; The University of Hong Kong-Shenzhen Institute of Research and Innovation, Shenzhen 518057, China.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jul 30; Vol. 121 (31), pp. e2400678121. Date of Electronic Publication: 2024 Jul 25.
DOI:	10.1073/pnas.2400678121
Abstrakt:	Recollecting painful or traumatic experiences can be deeply troubling. Sleep may offer an opportunity to reduce such suffering. We developed a procedure to weaken older aversive memories by reactivating newer positive memories during sleep. Participants viewed 48 nonsense words each paired with a unique aversive image, followed by an overnight sleep. In the next evening, participants learned associations between half of the words and additional positive images, creating interference. During the following non-rapid-eye-movement sleep, auditory memory cues were unobtrusively delivered. Upon waking, presenting cues associated with both aversive and positive images during sleep, as opposed to not presenting cues, weakened aversive memory recall while increasing positive memory intrusions. Substantiating these memory benefits, computational modeling revealed that cueing facilitated evidence accumulation toward positive affect judgments. Moreover, cue-elicited theta brain rhythms during sleep predominantly predicted the recall of positive memories. A noninvasive sleep intervention can thus modify aversive recollection and affective responses. Competing Interests: Competing interests statement:The authors declare no competing interest.
Databáze:	MEDLINE
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