Neurons for infant social behaviors in the mouse zona incerta.

Autor: Li Y; Laboratory of Physiology of Behavior, Department of Comparative Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA.; Department of Comparative Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA., Liu ZW; Department of Comparative Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA., Santana GM; Laboratory of Physiology of Behavior, Department of Comparative Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA.; Department of Neuroscience, School of Medicine, Yale University, New Haven, CT 06520, USA., Capaz AM; Laboratoire de Plasticité Structurale, Sorbonne Université, ICM Paris Brain Institute, INSERM U1127, CNRS UMR7225, AP-HP, 75013 Paris, France., Doumazane E; Laboratoire de Plasticité Structurale, Sorbonne Université, ICM Paris Brain Institute, INSERM U1127, CNRS UMR7225, AP-HP, 75013 Paris, France., Gao XB; Department of Comparative Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA., Renier N; Laboratoire de Plasticité Structurale, Sorbonne Université, ICM Paris Brain Institute, INSERM U1127, CNRS UMR7225, AP-HP, 75013 Paris, France., Dietrich MO; Laboratory of Physiology of Behavior, Department of Comparative Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA.; Department of Comparative Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA.; Department of Neuroscience, School of Medicine, Yale University, New Haven, CT 06520, USA.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2024 Jul 26; Vol. 385 (6707), pp. 409-416. Date of Electronic Publication: 2024 Jul 25.
DOI: 10.1126/science.adk7411
Abstrakt: Understanding the neural basis of infant social behaviors is crucial for elucidating the mechanisms of early social and emotional development. In this work, we report a specific population of somatostatin-expressing neurons in the zona incerta (ZI SST ) of preweaning mice that responds dynamically to social interactions, particularly those with their mother. Bidirectional neural activity manipulations in pups revealed that widespread connectivity of preweaning ZI SST neurons to sensory, emotional, and cognitive brain centers mediates two key adaptive functions associated with maternal presence: the reduction of behavior distress and the facilitation of learning. These findings reveal a population of neurons in the infant mouse brain that coordinate the positive effects of the relationship with the mother on an infant's behavior and physiology.
Databáze: MEDLINE
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